Bagothyrox is a preparation of thyroid hormones.
Release form and composition
Available in the form of tablets containing:
- 50 mcg, 100 mcg or 150 mg of levothyroxine sodium;
- Additional components, such as sodium croscarmellose, powdered cellulose, magnesium stearate, microcrystalline cellulose, lactose monohydrate, dye quinoline yellow.
Implemented tablets of 10 pcs. in blisters packed in cardboard boxes, and 1000 pcs. in plastic containers.
Indications for use
According to the data specified in the instructions for Bagrotirox, this drug is intended for the treatment of:
- Euthyroid goiter;
- Diffuse toxic goiter after it is possible to achieve the euthyroid state with thyreostatics;
- Thyroid cancer (after surgery).
Also, Bagothyrox, according to the instructions, is prescribed for the prevention of relapse and as a goiter replacement therapy after resection of the thyroid gland.
In addition, the drug is used when conducting a test of thyroid suppression (as a diagnostic tool).
According to the annotation to the drug, the use of Bagothyrox is contraindicated in:
- Untreated thyrotoxicosis;
- Acute myocarditis;
- Untreated adrenal insufficiency;
- Acute myocardial infarction;
- Hypersensitivity to levothyroxine or any auxiliary component.
Prescribe the drug, but with extreme caution and under constant medical supervision in patients with:
- Ischemic heart disease, including atherosclerosis, myocardial infarction, or angina in history;
- Malabsorption syndrome;
- Diabetes mellitus;
- Long-term severe hypothyroidism.
Dosing and Administration
The daily dose and duration of use of Bagotorox is determined by the attending physician, taking into account the indications. Tablets are taken once a day in the morning on an empty stomach (at least 30 minutes before breakfast).
When conducting replacement therapy for hypothyroidism, the drug is prescribed:
- Patients under the age of 55 years on the condition that they have no cardiovascular diseases: women - 75-100 mcg per day, men - 100-150 mcg;
- Patients older than 55 years, but if they have associated diseases of the cardiovascular system: in the initial daily dose of 25 mg, then every 2 months the dose is increased by 25 mg until normalization of thyroid stimulating hormone (TSH) in the blood. If the cardiovascular ailment worsens or develops, correction of the treatment of the underlying disease is necessary.
When treating congenital hypothyroidism, Bagothyrox is prescribed taking into account the age of the patient:
- Newborns up to 6 months - 10-15 mcg per kilogram, per day - 25-50 mcg;
- Babies from 6 to 12 months - 6-8 mcg / kg, per day - 50-75 mcg;
- Children 1-5 years old - 5-6 mcg / kg, per day - 75-100 mcg;
- Children 6-12 years old - 4-5 mcg / kg, per day - 100-150 mcg;
- Children over 12 years old - 2-3 mcg / kg, per day - 100-200 mcg.
With thyrotoxicosis, the drug is prescribed at a dose of 50-100 mcg per day. They begin to take it after reaching the euthyroid state and, as a rule, as part of complex therapy simultaneously with thyreostatics.
For the treatment of euthyroid goiter, Bagothyrox is taken in a dose of 75-200 mg. In the same dosage, the drug is prescribed to prevent the recurrence of euthyroid goiter after surgical treatment.
As a suppressive treatment of thyroid cancer, Bagothyrox is used in a dose of 50-300 mg per day.
During the thyroid suppression test, Bagothyrox is prescribed as follows: four weeks before the test, the drug is started to be taken 75 µg per day for two weeks, 2 weeks before the test, the daily dose is increased to 150-200 µg and taken until the day of the study.
The duration of treatment in all cases is determined individually. In hypothyroidism, the drug is usually taken throughout life.
According to the patient reviews, when using Bagothyrox in the doses recommended by a doctor and under his control, there are no side effects.
In rare cases, in the presence of hypersensitivity or intolerance to one or another component of the drug, allergic reactions may occur.
If hypothyroidism is caused by damage to the pituitary gland, before starting treatment, an examination should be carried out on the subject of adrenal insufficiency. If this condition is confirmed, in order to prevent the development of acute adrenal insufficiency, prior to the use of thyroid hormone, it is necessary to initiate replacement therapy with glucocorticosteroids.
As a monotherapy for hypothyroidism, Bagothyrox continues to be taken during pregnancy, only the dose is increased, because during this period, the level of thyroxin-binding globulin increases. It is forbidden during pregnancy to use Bagothyrox in combination with thyreostatics, since, unlike levothyroxine, they can penetrate the placenta and, therefore, provoke the development of hypothyroidism in the fetus.
When using Bagothyrox (even in high doses), the amount of thyroid hormone secreted in breast milk is not enough to provoke the development of any disorders in the child. For this reason, it is possible to take this medication during lactation, but strictly in recommended doses and under the supervision of a physician.
The following drugs are analogues of Bagothyrox:
- According to the active substance: L-Thyroxine, Levothyroxine, L-Thyroxine-Acre, L-Thyroxine Hexal, L-Thyroxine-Farmak, Eutirox;
- According to the mechanism of action: Yodocomb, Jodtirox, Novotiral, Tirecomb, Tireot, Triiodtironin 50 Berlin-Chemie.
Terms and conditions of storage
Bagothyrox is a drug belonging to the list B and released from pharmacies by prescription. Its shelf life is 2 years if it is stored in a protected from direct sunlight, but in a dry place at temperatures up to 25 ºС.