Azopt is an antiglaucoma drug.
Release form and composition
The drug is available in the form of 1% eye drops, 1 ml of which contains:
- 10 mg of brinzolamide;
- Excipients: preservative benzalkonium chloride 0.01%, tyloxapol, mannitol, disodium edetate, carbomer 974P, solution of hydrochloric acid or sodium hydroxide, purified water.
Drops in Drop Tainer plastic bottles of 5 ml, equipped with a dropper, are sold.
Indications for use Azopt
As indicated in the official instructions to Azopt, this drug is designed to reduce elevated intraocular pressure in diseases such as ocular hypertension and open-angle glaucoma.
According to the annotation to the drug, the use of Azopt is prohibited:
- In the presence of hypersensitivity to brinzolamid or any of its auxiliary components;
- Patients with renal insufficiency (if creatinine clearance does not reach the mark of 30 ml per minute);
- During lactation.
Azopt is prescribed, but with great care and under constant medical supervision, to people with hepatic insufficiency and angle-closure glaucoma, since the effect of the drug on the human body in these diseases has not been studied.
Adequate clinical studies of the safety of Azopt during pregnancy have not been conducted. For this reason, pregnant women are prescribed this drug strictly according to the indications and only if the intended benefit for the future mother outweighs the possible risks to her baby.
It is not known if brinzolamide is excreted in breast milk. Therefore, if it is necessary to undergo a course of treatment with Azopt in the period of lactation, breastfeeding is recommended to stop.
Do not prescribe the drug to children and adolescents under 18 years old, since the efficacy and safety of brinzolamide in pediatrics has not been established.
Dosage and dosage Azopt
Azopt, according to the instructions, you need to drip 1 cap. into the conjunctival sac of the affected eye two or three times a day.
The duration of treatment is determined by the attending physician depending on the severity of the course of the disease.
Side effects of Azopt
Reviews of patients who were treated with Azopt show that this drug may have side effects:
- In 5-10% of cases, they are expressed sour, bitter or unusual taste in the mouth, blurred vision;
- In 1-5% of patients, there is a sensation of a foreign body, dryness, pain and itching in the eye, dermatitis, headache, blepharitis, conjunctivitis hyperemia, discomfort, discharge from the eyes, rhinitis;
- Less than 1% of patients complain of: local reactions - diplopia, lacrimation, keratoconjunctivitis, conjunctivitis, asthenopia, keratopathy, formation of crusts on the eyes; systemic reactions - shortness of breath, dizziness, dry mouth, pain in the chest and lower back, hypertension, nausea, dyspepsia, diarrhea, alopecia, pharyngitis.
Also Azopt, according to reviews, can cause allergic reactions, manifested by itching, swelling and conjunctival hyperemia, urticaria.
Sensitization (specific hypersensitivity) of the body to brinzolamide may develop if the drug is used repeatedly and in violation of the dosing regimen. If there are signs of hypersensitivity or serious side effects, you should immediately stop using Azopt and consult a doctor.
It should be borne in mind that brinzolamide - the active substance of Azopt - is a sulfonamide, when applied topically, its systemic absorption occurs, and therefore serious adverse reactions may develop, including fatal ones: agranulocytosis, toxic epidermal necrolysis, malignant exudative erythema, hepatonecrosis, aplastic anemia and other disorders of blood formation.
Cases of overdose of Azopt were not recorded. In case of accidental oral administration of the drug may develop acidosis, disorders of the nervous system and electrolyte balance.
Before use, the bottle should be shaken. During instillation, make sure that the pipette tip does not touch the eye or any other surface (in order to avoid infection).
Azopt contains benzalkonium chloride as a preservative. This substance can be absorbed by contact lenses. Therefore, before burying, they need to be removed, and set back no sooner than after 15 minutes.
Azopt is not recommended to be used simultaneously with other carbonic anhydrase inhibitors, as well as with salicylates in high doses, since electrolyte and acid-base balance may be disturbed.
If you need to use another ophthalmic drug, it is important to observe the minimum 10-minute interval between instillation.
Immediately after instillation of the drug may blurred vision, and in some people - drowsiness. Therefore, for at least 30-60 minutes you should refrain from driving a car and performing potentially dangerous tasks that require quick reactions and good vision.
Analogs of Azopt
The pharmaceutical industry does not produce structural analogues of Azopt with the same active ingredient. In case of intolerance to the components of the drug should contact your doctor, who will select a drug with the same properties, but other active ingredients.
According to belonging to the same pharmacological group and similarity of the mechanisms of action, the analogues of Azopt include Diakarb, Diuremid, Doramed.
Terms and conditions of storage
Azopt is an antiglaucoma prescription drug. On condition that the storage conditions recommended by the manufacturer are observed - dry, protected from direct sunlight and a cool place - its shelf life is 5 years. After opening the bottle drops can be stored no more than 4 weeks.