Azaleptin is included in the group of antipsychotic drugs, neuroleptics.
Release form and composition
The only form of release of the drug are tablets 25 and 100 mg. Tablets are packed or in contour cells of 10 pieces each, or in cans of light-protective glass of 50 pieces. Both forms of release are located in cardboard boxes. One box contains 1 bank or 5 contour cells.
Each Azaleptin tablet contains clozapine (azaleptin) in the amount of 25 or 100 mg. Auxiliary additives are: lactose monohydrate or milk sugar - 0.101 / 0.11 g (in tablets with clozapine 25 mg and 100 mg, respectively), calcium stearate - 0.0015 and 0.0025 g, potato starch - 0.0225 and 0.375
Indications for use Azaleptina
According to the instructions to Azaleptin, treatment with the help of the drug is advisable for disorders of the nervous system listed below:
- For acute or chronic schizophrenia;
- With manic states;
- With manic-depressive psychosis;
- With psychomotor agitation arising on the background of psychopathy;
- With behavioral and emotional disorders, including in pediatric patients;
- With sleep disorders of various origins.
Azaleptin is not recommended for use in agranulocytosis, granulocytopenia in history (except for cases of development of diseases after chemotherapy), in the suppression of bone marrow hematopoiesis, in comatose conditions, in myasthenia, in toxic psychosis (including alcohol), in pregnancy and in lactation , in the presence of hypersensitivity to azaleptin. Also, Azaleptin-based therapy should not be given to children under 5 years of age.
Dosage and administration Azaleptina
The drug is administered orally, after meals, with a tablet of water or other liquid. The frequency of admission per day is 2 to 3 times.
A single dose for adults should not be more than 200 mg, the initial daily dose is in the range of 150-300 mg, the average daily dose is 200-400 mg, and the maximum recommended dosage per day can not exceed 600 mg. Dosages are selected individually, starting with 25 mg Azaleptine. Subsequently, the amount of the drug is increased by 25-50 mg every day until the therapeutic effect is achieved.
For the treatment of mild forms of diseases, as well as people with renal and hepatic insufficiency, cerebrovascular disorders, and heart failure in chronic form, a lower daily dosage is prescribed, ranging from 20 to 200 mg.
During treatment, it is necessary to take into account the fact that the therapeutic effect is achieved in stages: first, hypnotic and sedative effects are manifested; then restlessness, psychomotor agitation and aggressiveness are stopped (after a week of intake); after 2 weeks an antipsychotic effect occurs; symptoms of negativity are reduced after 20-40 days. After achieving the desired result, you should proceed to a course of maintenance therapy.
Side effects of azaleptin
The instructions to Azaleptin list possible negative reactions to the drug, which must be reviewed before starting treatment:
- Headache, akathisia, agitation, drowsiness, confusion, insomnia, extrapyramidal disorders (which include hypokinesia, tremor, akinesia, muscle stiffness), depression, restless sleep, SNS, tardive dyskinesia, epileptic seizures;
- Hypotension, tachycardia, arterial hypertension, orthostatic hypotension and dizziness in its background;
- Nausea, heartburn, hypersalivation, dry mouth, vomiting;
- Increased sweating, a sharp increase in body weight;
- Leukopenia, eosinophilia, thrombocytopenia, granulocytopenia;
- Accommodation disturbances, constipation, dry mouth, urination disorders;
- Decreased potency.
The drug is allowed for use by persons with diseases of the cardiovascular system in severe forms, with severe renal or hepatic insufficiency, with hyperplasia of the prostate gland, with angle-closure glaucoma, with intestinal atony, epilepsy.
Periodic monitoring of peripheral blood is recommended during the use of Azaleptine.
During the period of treatment with medication should stop drinking alcohol.
The drug is not recommended for children under 16 years, because there are no studies confirming its effectiveness and safety for this group of patients.
Azaleptin has an impact on the speed of psychomotor reactions, in connection with this control of complex mechanisms during its reception is unacceptable.
Analogs of Azaleptine
The instructions to Azaleptin indicate the following analogs of the drug:
Terms and conditions of storage
Azaleptin is a potent drug and should be kept away from children’s access. The shelf life of the drug is 5 years from the date of issue. It is necessary to choose a dark place for storage where the temperature does not rise above 30 ° C.