Azafen is a psychotropic drug, tricyclic antidepressant. It has a sedative and sedative effect, aimed at balancing certain elements of the brain that are responsible for the state of depression. Azafen reduces anxiety and excitement. The drug is an antidepressant of the old format, it was developed and received permission to use in 1970. However, until now, its high efficacy is confirmed by positive reviews from patients and numerous studies of the drug. One of the latest studies was conducted in 2005, for one and a half months, people with depression were given Asafen. As a result, 53% had a complete recovery, the rest had minor symptoms of the disease. First of all, the drug relieves anxiety, lethargy, improves mood.
The main plus of Azafen in comparison with other tricyclic antidepressants is that this drug has a low toxic effect on the body, including the heart, and it does not block cholinreceptors and does not change the activity of monoamine oxidase. The maximum concentration in the blood is reached 1-2 hours after taking the drug. It is absorbed in the gastrointestinal tract, the metabolism occurs in the liver, and Azafen is excreted by the kidneys.
Release form and composition
The main active ingredient of the drug is pipofezin. Each tablet of Azafen contains 25 g of pipofesin, as well as excipients: potato starch, colloidal silicon dioxide, microcrystalline cellulose, lactose monohydrate, povidone and magnesium stearate. The form of release of Azafen - tablets of yellowish-green color of a flat-cylindrical form, are packed into contour cellular plates of 10 or 14 pieces, which, in turn, are produced in cardboard packs.
Indications for use Azafen
According to the instructions, shows the use of Azafen in the following cases:
- Depressive states of any nature, including asthenic states, accompanied by neuropsychiatric weakness;
- Somatogenic depression - conditions caused by severe bodily illnesses (characteristic of cancer patients, hypertensive patients and people with severe chronic diseases);
- Depressive anxiety syndrome;
- Depression caused by a reaction to the loss of a loved one;
- Organic depression - conditions caused by brain damage (eg, multiple sclerosis);
- Senile depression;
- Affective insanity;
- Alcohol-induced depression;
- Depression caused by prolonged use of drugs that inhibit the activity of the central nervous system.
The use of Azafen is especially effective for the treatment of mild to moderate depressive states. In more severe forms of the disease, it is recommended to take Azaphen as part of a combination therapy with other stronger antidepressants. The drug can be used by people with ischemic heart disease and glaucoma, as it has no cardiotoxic and anticholinergic action.
The instructions to Azafen indicated that the drug is contraindicated for people who have an increased sensitivity to the components of this drug, who suffer from liver failure, have had a heart attack and stroke, patients with heart failure, diabetes and infectious diseases. Categorically you can not take the drug during pregnancy and breastfeeding. Azafen not combined with MAO inhibitors. Children can only be prescribed by a doctor, and the reception should be under constant supervision. Azafen’s safety record for children is not enough. Before you start the use of Azafen, you should completely abandon the use of alcohol.
Method of administration and dosage of Azafen
The instructions to Azafen indicated that at the initial stage of treatment, 1-2 tablets (25-50 mg) should be taken twice a day - in the morning and at lunch. The drug must be taken after meals. With positive results of treatment and in the absence of side effects, the dosage should be increased to 6-8 tablets (150-200 mg) and split it into 2-3 doses per day. For the treatment of severe forms of depression daily dosage can reach 400-500 mg. After the desired effect is achieved, you can reduce the dose to 1-3 tablets (25-75 mg) per day. When prescribing the drug can not use only the instructions to Azafen, any antidepressant should be chosen by the attending physician after examining the patient. And only a doctor can choose the right dosage and determine the duration of the course of treatment. Azafen is usually taken for a long time, from 1 month to 1 year.
Side effects of azafen
Azafen is fairly well tolerated by patients, reviews indicate that side effects are rare, and the drug affects the body gently. At the beginning of the pill, you may experience a feeling of dry mouth, weakness, drowsiness, and disruption of attention. Headache is possible, rarely - nausea, vomiting, dizziness and allergic reactions. In case of overdose, all the listed symptoms may worsen. If any side effects occur, reduce the dosage of the drug.
During treatment, Azafen is absolutely not allowed to drink alcohol. Should regularly monitor the functioning of the kidneys and liver. During the period of treatment it is better to refrain from classes that require increased concentration and quick reaction. It is not recommended to drive vehicles.
Analogue of Azafen is Pipofezin.
Terms and conditions of storage
The drug should be stored in a dark dry place at a temperature not higher than 25 ° C for 5 years.