Aurobin - glucocorticosteroid with anti-inflammatory, local anesthetic and antibacterial action, used in proctology.
Release form and composition
The drug is produced in the form of a homogeneous ointment intended for external and rectal use, 1 gram of which contains:
- 20 mg of D-panthenol;
- 20 mg lidocaine hydrochloride;
- 2 mg of prednisolone capronate;
- Excipients such as oil neutral, macrogol stearate, methyl parahydroxybenzoate, polysorbate 60, glycerol, stearic acid, triclosan, cetyl alcohol, liquid paraffin, propylene glycol, dimethicone and purified water.
Aurobin ointment is sold by 20 grams in aluminum tubes packed in cardboard boxes.
Indications for use
As indicated in the instructions for Aurobin, this drug is intended for the treatment of:
- Processes involving inflammation of the perianal region;
- Fistula anus;
- Anal fissures;
- Itching anus;
- Dermatitis and eczema of the perianal area.
According to the annotations to the drug, the use of Aurobina is contraindicated:
- In the treatment of fungal, viral and bacterial infections of the skin;
- Children up to 1 year;
- Simultaneously with drugs containing lidocaine, according to other indications;
- In the presence of hypersensitivity to any active or auxiliary component.
The drug is not prescribed in the first trimester of pregnancy, when the organs and systems of the fetus are formed, due to the lack of data on the efficacy and safety of using Aurobin in this period of a woman’s life. In the second and third trimesters, the drug is prescribed, but strictly according to the indications and carefully comparing the expected benefits for the future mother and the possible risks to her child.
Both lidocaine and corticosteroids penetrate into breast milk, so feeding the baby for the period of treatment with Aurobin should be stopped.
Dosing and Administration
Ointment Aurobin, according to the instructions, should be used only externally and rectally. The tool is applied to the affected area two to four times a day.
When treating internal hemorrhoids, a small amount of ointment is injected into the rectum after spontaneous defecation or cleansing enema, 2-4 times a day.
As the symptoms of the disease decrease, the frequency of use of the drug is reduced to 1-2 times a day.
The duration of Aurobin therapy is 5-7 days, depending on the indication. If after 5 days from the start of treatment, there is no positive change in treatment, you should contact your doctor for re-diagnosis and, possibly, adjustment of the therapeutic regimen.
Reviews of patients who used Aurobin personally or used it to treat their children indicate that in most cases this drug is well tolerated. In rare cases, the ointment causes irritation, burning sensation, thinning and increased skin sensitivity, rashes and dryness at the site of application.
With prolonged use of Aurobina, especially under the occlusive dressing, systemic side effects may develop, such as:
- Characteristic of corticosteroids: atrophy of the skin, purpura, local hirsutism, hypopigmentation, folliculitis, the development of fungal infections, acne-like rashes, hypertrichosis, telangiectasia, diaper rash, allergic contact dermatitis, suppression of the function of the adrenal cortex;
- Characteristic of lidocaine: hyperthermia, depression of the immune system, nausea, angioedema, collapse, impaired cardiac conduction, convulsions, sinus bradycardia, respiratory depression, impaired consciousness, drowsiness, agitation or depression of the central nervous system.
Depending on the amount of absorbed lidocaine and prednisone, the development of such side effects of Aurobin is not excluded:
- Cushing's syndrome, a decrease in the level of potassium in the blood, fluid and sodium retention in the body, hypercorticism, hypokalemic alkalosis (from the metabolic and endocrine system);
- Sleep disturbances, dizziness, increased intracranial pressure, headache, convulsions, mental disorders (on the part of the nervous system);
- Cataract (including subcapsular), exophthalmos, glaucoma, corneal ulcer, chorioretinopathy, optic nerve edema (from the senses);
- Pancreatitis, peptic ulcer and 12 duodenal ulcers, gastrointestinal bleeding, esophagitis, perforation of the digestive tract organs (from the digestive system);
- Arterial hypertension, heart failure, reduced myocardial conductivity, peripheral vasodilation (on the part of the cardiovascular system);
- Urticaria, dermatitis, purpura, thinning and atrophy of the skin, hyperhidrosis, erythema, dermatitis, folliculitis, acne, pigmentation disorders, telangiectasia, hirsutism, striae (skin reactions and allergic reactions);
- Osteoporosis, slowing of regenerative processes, negative nitrogen balance, growth retardation, steroid myopathy, increased intraocular pressure (other reactions).
Also Aurobin, according to reviews, can mask the symptoms of infectious diseases, and in isolated cases it can cause the activation of subclinical and opportunistic infections.
Doctors recommend using the drug in minimal doses that achieve a therapeutic effect, and if possible for a short period of time, especially in children, because With prolonged treatment, there is a possibility of suppression of adrenal function.
Before each use of Aurobina you need to clean and dry the skin, because wet conditions contribute to the development of a bacterial infection.
According to the mechanism of action, Aurobin's analog is Sulfodekortem ointment.
Terms and conditions of storage
Aurobin - prescription drug. Its shelf life is 2 years if it is stored in a place protected from direct sunlight at a temperature not higher than 15 ºС, but not lower than 8 ºС.