Augmentin is an antimicrobial agent intended for systemic use.
Release form and composition
Augmentin is produced in the form of white oval tablets in a film shell, on one side of which there is a dented inscription “AUGMENTIN”, in blisters of 10 pieces each.
Each of them contains 250 mg of amoxicillin, 125 mg of clavulanic acid and the following excipients - 650 mg of microcrystalline cellulose, 13 mg of sodium carboxymethyl starch, 6.5 mg of colloidal silicon dioxide and magnesium stearate each.
The film casing contains 4000 and 6000 each of 1.46 mg, 6000 and 6000, 0.013 mg of dimethicone, 9.63 mg of titanium dioxide, 2.46 mg of hypromellose (15cP) and 7.39 mg of hypromellose (5cP).
Also produced are white oval film-coated Augmentin tablets, with a risk mark and the words “AU” on one side, in blisters of 7 and 10 pcs.
One tablet contains 0.5 g of amoxicillin and 125 mg of clavulanic acid, as well as excipients - 21 mg of sodium carboxymethyl starch, up to 1.05 g of microcrystalline cellulose, 7.27 mg of magnesium stearate and 10.5 mg of colloidal silicon dioxide.
The shell contains 0.013 mg of silicone oil, 11.6 mg of titanium dioxide, 1.75 mg of macrogol 4000 and 6000, 2.97 mg of hypromellose (15cP) and 8.91 mg of hypromellose (5cP).
Another form of Augmentin’s production is oval white, film-coated tablets, on both sides of which there are letters “A” and “C”, 7 pieces each. in blisters. The composition of 1 pc. 875 mg of amoxicillin and 125 mg of clavulanic acid are included. Also, each tablet contains such excipients as:
- 14.5 mg of magnesium stearate;
- 10 mg of colloidal silicon dioxide;
- 29 mg sodium carboxymethyl starch;
- 396.5 mg microcrystalline cellulose.
The film-coating film shell contains 2,08 mg of macrogol 4000 and 6000, 13.76 mg of titanium dioxide, 10.56 mg of hypromellose (5cP), 0.013 mg of dimethicone and 3.52 mg of hypromellose (15 cps).
Indications for use
In accordance with the instructions, Augmentin is prescribed for the treatment of bacterial infections of the lower and upper respiratory tract, skin, urinary tract, soft tissues, joints and bones caused by susceptible microorganisms, as well as with septic abortion, postpartum and intra-abdominal sepsis, septicemia, peritonitis and peritonitis. postoperative infections.
Augmentin's use is contraindicated in jaundice or abnormal liver function associated with a previous intake of the drug, as well as in cases of hypersensitivity of patients to the components of the drug.
Dosing and Administration
According to the instructions, Augmentin is administered intravenously slowly over 3-4 minutes, or within half an hour. For children younger than 3 months, the agent is administered only by infusion.
The dosage of the drug is determined individually, depending on the severity of the infection, kidney function, body weight and the age of the patient. The dose of the drug is expressed as the content of amoxicillin / clavulanate, namely:
- Adults are prescribed every eight hours at 1000 mg / 200 mg, in cases of severe infections, the same dose is used every 4-6 hours;
- Patients staying on hemodialysis are first given a dose of 1 g / 200 mg, and then it is reduced to 0.5 g / 100 mg and used every 24 hours.
The dose of funds for children is determined based on the age and body weight, namely:
- Children younger than 3 months with a body weight less than 4 kg should be prescribed 25 mg / 5 mg per 1 kg or 50 mg / 5 mg per 1 kg twice a day, for children from 3 months with a weight greater than 4 kg, the dosage of the agent is the same, however applied three times a day;
- For patients aged 3 months to 12 years, the dose of the drug is also 25 mg or 50 mg / 5 mg per 1 kg of body weight, and it is used 3-4 times a day.
The duration of Augmentin therapy can be a maximum of 2 weeks.
When used, Augmentin may cause side effects from some body systems, namely:
- Leukopenia, thrombocytopenia, hemolytic anemia, agranulocytosis and an increase in prothrombin time (hematopoietic system);
- Dizziness, hyperactivity, headache and convulsions (CNS);
- Crystalluria and interstitial nephritis (urinary system);
- Diarrhea, nausea, vomiting and dyspepsia (digestive system);
- Moderate increases in alanine aminotransferase or aspartate aminotransferase, hepatitis and cholestatic jaundice (liver).
Augmentin can also cause the following side reactions:
- Angioedema, allergic vasculitis, anaphylaxis, bullous exfoliative dermatitis and toxic epidermal necrolysis (allergic reactions);
- Skin rash, erythema multiforme, and urticaria (dermatological reactions).
Before using Augmentin, it is recommended to collect data on the history relating to the patient's previous hypersensitivity reaction to cephalosporins, penicillins and other allergens.
If an allergic reaction is observed during drug therapy, the use of the medication should be immediately stopped and an alternative treatment should be prescribed.
In cases of serious hypersensitivity reactions, the patient must immediately enter adrenaline, intravenous glucocorticosteroids and oxygen therapy may also be required.
Kronosar, Rapiklav, Amoxiclav, Baktoklav, Arlet, Panklav, Medoklav, Liklav and Ekoklav are the synonyms of the drug.
Augmentin analogues are such drugs as:
- Trifamox IBL;
Terms and conditions of storage
According to the instructions, Augmentin in any form of release should be stored in a dry place inaccessible to children and light at room temperature. The shelf life of the powder is two years, tablets - 3 years.
Ready suspension is recommended to store no more than 1 week in the refrigerator. Release Augmentin from pharmacies with a doctor’s prescription.