Atropine is an anticholinergic drug that also has a spasmolytic effect and is used in the treatment of diseases of the gastrointestinal tract, respiratory system, cardiology and ophthalmology.
Release form and composition
Atropine is available as a solution for injection and eye drops, the main active ingredient of which is atropine sulfate.
Atropine Injection Solution is available in 0.1 and 0.05% in 10 ampoules per pack.
Eye drops are available in bottles of 5 and 10 ml.
Indications for use
According to the instructions, Atropine is used for:
- Spasms of the bile ducts, smooth muscles of the digestive tract, bronchi;
- Peptic ulcer disease;
- Acute pancreatitis;
- Hypersalivation (intoxication with heavy metal salts, parkinsonism, dental interventions;
- Irritable bowel syndrome;
- Renal and intestinal colic;
- Broncho-and laryngism;
- Bronchitis with hypersecretion;
- AV blockade;
- Poisoning with anticholinesterase substances and m-cholinomimetics;
- As premedication before surgical interventions;
- To reduce the tone of the stomach and intestines during X-ray examination of the digestive tract;
- Before researching the fundus;
- In order to expand the pupil and paralysis of accommodation in determining the true refraction of the eye;
- In the treatment of iritis, choroiditis, iridocyclitis, keratitis, some eye injuries, spasm and embolism of the central retinal artery.
According to the instructions, Atropine does not apply when:
- Patient hypersensitivity to Atropine;
- Keratoconus, open-and closed-angle glaucoma.
The drug should be used with caution:
- In renal and hepatic impairment;
- In cardiovascular diseases in which an increase in heart rate is undesirable;
- With intestinal atony in elderly and debilitated patients;
- When hypertrophy of the prostate gland is not accompanied by obstruction of the urinary tract;
- With urinary retention, as well as the presence of a predisposition to it;
- In diseases that are accompanied by obstruction of the urinary tract;
- In young children with chronic lung diseases;
- With brain damage in children;
- With cerebral palsy;
- With Down's disease.
Dosing and Administration
The recommended dosage of Atropine, according to the instructions - 300 mg every 4-6 hours.
In order to eliminate bradycardia, Atropine is administered to adults at a dose of 0.5–1 mg, for children — 10 µg per kilogram of weight.
As premedication, Atropine is administered intramuscularly to adults - 45-60 minutes before anesthesia at a dose of 400-600 mcg; children - 10 micrograms per kilogram of weight.
Eye drops are instilled 1-2 drops into the affected eye up to 3 times with an interval of 5-6 hours. In some cases, Atropine solution may be administered parabulbally or subconjunctivally. When conducting electrophoresis, the solution is injected from the anode through the eyelids or eye bath.
When using Atropine, certain adverse reactions may occur:
- Nervous system and sensory organs: dizziness, headache, insomnia, euphoria, confusion, hallucinations, accommodation paralysis, mydriasis, impaired tactile sensitivity;
- Cardiovascular system and blood system: aggravation of myocardial ischemia, sinus tachycardia, ventricular fibrillation, ventricular tachycardia;
- Digestive system: constipation, xerostomia;
- Other: urinary retention, intestinal and bladder atony, fever, photophobia;
- Local reactions: tingling in gases, increased intraocular pressure, irritation, skin flushing on the eyelids, hyperemia and swelling of the conjunctiva, mydriasis and accommodation paralysis, conjunctivitis.
When using Atropine, it should be borne in mind that:
- The interval between taking this drug and antacids containing calcium carbonate or aluminum should be at least 60 minutes;
- In order to reduce tachycardia with parabulbar and subconjunctival administration of Atropine, the patient must take validol;
- When driving a car and performing other potentially hazardous activities associated with an increased rate of psychomotor reactions, high concentration of attention and good eyesight, care must be taken;
- This tool enhances the effect of anticholinergic drugs;
- This drug slows the absorption of mexiletin, zopiclone, nitrofurantoin;
- You may increase blood pressure while taking this drug at the same time as phenylephrine;
- The drug reduces the level of levodopa in the blood;
- The hyposecretory effect of the drug is reduced by the action of guanethidine;
- Taking nitrates at the same time as Atropine increases the risk of increasing intraocular pressure;
- Taking procainamide enhances the anticholinergic effect of this drug.
An analogue of Atropine is the drug Atropine sulfate.
Terms and conditions of storage
The drug is stored in places inaccessible to children at a temperature of above 25 º for no more than five years.