Atorvastatin is a lipid-lowering drug.
Release form and composition
Atorvastatin tablets are made containing the active substance - atorvastatin - in the amount of 10, 20, 40 or 80 mg.
Auxiliary substances are: microcrystalline cellulose, calcium carbonate, colloidal silicon dioxide, macrogol, titanium dioxide, magnesium stearate, polyvinyl alcohol, pregelatinized starch, lactose monohydrate.
In blister packs of 10 tablets.
Indications for use
According to the instructions, atorvastatin is indicated for:
- Reduced levels of total Xc, Xc-LDL, apolipoprotein B and TG and increased levels of Xc-HDL in heterozygous familial or non-familial hypercholesterolemia, primary hypercholesterolemia, mixed hyperlipidemia type IIa and IIb according to Fredrikson (in combination with diet);
- Therapy of patients with elevated serum levels of TG (type IV according to Fredrickson), dysbetalipoproteinemia (type III according to Fredrickson) with insufficient effect of diet therapy;
- Reducing the level of total Xc and Xc-LDL in patients with homozygous familial hypercholesterolemia in case of insufficient efficacy of diet therapy and other non-pharmacological treatment methods.
According to the instructions, atorvastatin is contraindicated in:
- Increased liver enzymes of unexplained etiology;
- Diseases of the liver in the active phase;
- Pregnancy and breastfeeding;
- Hepatic insufficiency (grades A and B on the Child-Pugh scale);
- Hypersensitivity to atorvastatin or auxiliary components of the drug.
Atorvastatin is not prescribed at the age of 18 years, as the efficacy and safety of the drug for this age group has not been established.
In the application of atorvastatin, caution should be exercised when:
- Chronic alcoholism;
- Severe electrolyte imbalance;
- Skeletal muscle diseases;
- Extensive surgical interventions;
- Severe acute infections;
- Metabolic and endocrine disorders;
- Uncontrolled epilepsy;
- Liver disease in history.
Dosing and Administration
Atorvastatin is intended for internal use. Take medicine at any time of the day with food. To select the correct dose, you must set the level of Xc-LDL.
At the beginning of therapy and during the dose increase of atorvastatin, the patient should monitor plasma lipid levels once every 2-4 weeks in order to correct the dosage of the drug accordingly.
As a rule, the initial dose of atorvastatin is 10 mg once a day and further varies in the range of 10-80 mg per day.
In the case of a combination of Atorvastatin with cyclosporine, the daily dose should not exceed 10 mg.
A pronounced therapeutic effect of Atorvastatin is observed 2 weeks after the start of use, the maximum - in a month. With prolonged therapy, the effect is preserved.
The use of atorvastatin may cause the following side effects:
- Nervous system: dizziness, insomnia, asthenia, headache, paresthesias, nightmares, peripheral neuropathy, loss of consciousness, emotional lability, amnesia, ataxia, migraine, hyperkinesis, facial paralysis;
- Sense organs: dry conjunctiva, tinnitus, deafness, hemorrhage in the mucous membrane of the eye, disturbance of accommodation, glaucoma, loss of taste sensations;
- Cardiovascular system: palpitations, chest pain, orthostatic hypotension, arrhythmia, high blood pressure, angina pectoris, vasodilation symptoms;
- Blood system: thrombocytopenia, lymphadenopathy, anemia;
- Digestive system: nausea, stool disorders, heartburn, gastralgia, dry mouth, increased or decreased appetite, vomiting, belching, glossitis, esophagitis, melena, pancreatitis, bleeding gums, abdominal pain, cholestatic jaundice, abnormal liver function, tenesmus. In some cases, atorvastatin can cause rectal bleeding, duodenal ulcer;
- Respiratory system: rhinitis, bronchitis, dyspnea, pneumonia, nasal bleeding, exacerbation of asthma;
- Musculoskeletal system: bursitis, arthritis, leg muscle cramps, myositis, joint contractures, tendopathy, torticollis, swelling of joints, muscle hypertonia;
- Urogenital system: peripheral edema, urogenital infections, urinary retention or urinary incontinence, nephritis, vaginal bleeding, decreased libido, ejaculation disorder, hematuria, epididymitis;
- Skin reactions: photosensitivity, alopecia, eczema, petechiae, increased sweating;
- Endocrine system: mastodynia, gynecomastia;
- Metabolism: exacerbation of gout, weight gain;
- Allergies: skin rash, pruritus, urticaria, contact dermatitis, angioedema, toxic epidermal necrolysis.
Before starting to use atorvastatin, the patient should try to achieve control of hypercholesterolemia with an appropriate diet, weight loss (if necessary), and increase physical activity. Patients must follow the hypercholesterol diet throughout the entire period of treatment with atorvastatin.
Since one of the side effects of atorvastatin is dizziness, patients should be careful when driving vehicles and managing other potentially dangerous machinery.
Analogues of atorvastatin are the following drugs:
Terms and conditions of storage
According to the instructions, Atorvastatin should be stored in a dry dark place out of the reach of children, not longer than 3 years from the date of issue.