Atenolol is a cardioselective beta1-adrenergic blocker that has hypotensive, antiarrhythmic and antianginal effects.
Release form and composition
The drug is produced in the form of tablets, which contain:
- 25, 50 or 100 mg of atenolol;
- The following excipients: lactose, hydroxypropylmethylcellulose, sodium starch glycolate, corn starch, polyvinylpyrrolidone, isopropanol, sodium lauryl sulfate, magnesium stearate, purified talc, titanium dioxide, polyethylene glycol, colloidal silicon dioxide, a cleaned color unit, a colorless pattern.
Atenolol tablets are sold in 10 pcs. in blisters.
Indications for use
As indicated in the instructions for Atenolol, this drug is intended for:
- Arterial hypertension treatment;
- Prevention of angina attacks;
- Elimination of cardiac rhythm disorders, in particular, ventricular extrasystoles, sinus tachycardia, as well as prevention of supraventricular tachyarrhythmias.
According to the annotation to the drug, the use of Atenolol is contraindicated in:
- Cardiogenic shock;
- Sick sinus syndrome;
- Severe bradycardia (if the heart rate does not reach 40 beats per minute);
- Atrioventricular block of the second and third degrees;
- Sinoauricular blockade;
- Printsmetal angina pectoris;
- Decompensated chronic heart failure (both chronic and acute);
- Hypotension (if the systolic blood pressure is less than 100 mm Hg, as well as in the case of myocardial infarction);
- The presence of hypersensitivity to the active or any auxiliary component of the drug.
Do not take atenolol, according to the instructions, also:
- During lactation;
- Children and adolescents under 18 years old (due to the lack of data on the safety of use);
- Simultaneously with MAO inhibitors.
Atenolol is prescribed, but with extreme caution and under constant medical supervision, pregnant women, elderly people, patients with:
- Diabetes mellitus;
- Metabolic acidosis;
- Allergic reactions in history;
- AV blockade of the first degree;
- Emphysema and other chronic obstructive pulmonary diseases;
- Compensated chronic heart failure;
- Obliterating peripheral vascular diseases, including Raynaud's syndrome and intermittent claudication;
- Chronic renal / hepatic insufficiency.
Dosing and Administration
The specific dosage and duration of treatment with Atenolol is determined by the attending physician taking into account the indications, the tolerability of the drug and its clinical efficacy.
The standard dosage for adults, as a rule, is 25-50 mg once a day. If necessary, after 1-2 weeks (this is exactly what is needed to achieve a stable hypotensive effect), the dose is increased, but not more than 100 mg per day, because a further increase in dosage is not accompanied by an increase in the clinical effect, but is fraught with the development of side effects.
A single dose for people over the age of 65 is 25 mg, it can be increased, but strictly under the control of heart rate and blood pressure.
Dose adjustment of atenolol to the lower side is required for patients who have impaired renal function. The maximum allowable dosage for them:
- When CC from 15 to 35 ml / minute - 50 mg per day;
- When CC is less than 15 ml per minute - 50 mg every other day.
Patients on hemodialysis, the drug is prescribed 25-50 mg after each session of hemodialysis. It should be taken in a hospital under the supervision of a doctor, because There is a chance of lowering blood pressure.
Reviews of patients undergoing treatment with Atenolol indicate that this drug may have side effects, such as:
- Arrhythmia, marked reduction in blood pressure, bradycardia, impaired atrioventricular conduction, development of symptoms of chronic heart failure or exacerbation of existing ones, weakening of myocardial contractility, vasculitis, manifestations of angiospasm, chest pain, orthostatic hypotension;
- Dizziness, hallucinations, insomnia or drowsiness, slow reaction and ability to concentrate, depression, weakness, fatigue, anxiety, headache, confusion, nightmares, paresthesias in the extremities, muscle weakness, short-term memory loss, convulsions;
- Dry mouth, change in taste, nausea, abdominal pain, diarrhea or constipation, vomiting;
- Nasal congestion, bronchospasm, dyspnea, apnea;
- Visual impairment, soreness and dryness of the eyes, reduced tearing, conjunctivitis;
- Photosensitivity, dermatitis, skin flushing, urticaria, reversible alopecia, increased sweating, pruritus, urticaria, exacerbation of psoriasis;
- Thrombosis, aplastic anemia, platelet purpura;
- Hyperglycemia (in patients with non-insulin-dependent diabetes mellitus), hypoglycemia (in people receiving insulin), decreased libido and / or potency, hypothyroid states;
- Withdrawal syndrome, manifested by tachycardia, increased blood pressure, increased frequency of strokes, etc .;
- Thrombocytopenia, increased liver enzymes, leukopenia, agranulocytosis, hyperbilirubinemia.
When using Atenolol during pregnancy are possible:
- Fetal growth retardation.
Analogues of Atenolol are:
- According to the active substance: Betakard, Vero-Atenolol, Atenolol-Teva;
- On the mechanism of action: Aritel, Betak, Bidop, Bisogamma, Bisoprolol, Vazokardin, Konkor, Korvitol, Kordanum, Lokren, Metocard, Metoprolol, Nebivator, Nebikor, Serdol, Tyrese, Egilok S, etc.
Terms and conditions of storage
Atenolol is a prescription drug. Its shelf life is 2 years. Storage rules - dry, cool, protected from the sun place.