Arutymol is a beta-blocker that belongs to the group of antiglaucoma drugs.
Release form and composition
The medicine is produced in the form of 0.25% and 0.5% eye drops, in 1 ml of which there are:
- 2.5 or 5 mg of timolol (in the form of a hydromaleate), respectively;
- The following auxiliary components: sodium dihydrogen phosphate, disodium edetate dihydrate, sodium monohydrogen phosphate dodecahydrate, povidone, injectable water and, as a preservative, benzalkonium chloride.
Implemented drops of 5 ml in plastic bottles.
Indications for use
As indicated in the instructions for Arutimol, this drug is used for:
- Ocular hypertension (increased intraocular pressure);
- Secondary glaucoma, including aphakic;
- Open-angle glaucoma;
- Closed-angle glaucoma (in combination with miotics designed to reduce intraocular pressure);
- Congenital glaucoma.
According to the annotation to the drug, the use of Arutimol is contraindicated in:
- Sinus bradycardia;
- Corneal dystrophy;
- Bronchial asthma and other chronic obstructive respiratory diseases;
- AV blockade II and III degrees;
- Cardiogenic shock;
- Severe atrophic rhinitis;
- Allergic reactions, accompanied by generalized skin rashes;
- Severe heart failure;
- The presence of hypersensitivity to timolol or any auxiliary component of the drug.
Arutymol is prescribed, but with caution and under the constant supervision of a physician to patients with:
- Chronic heart failure;
- Diabetes mellitus;
- Pulmonary insufficiency;
- Severe cerebrovascular insufficiency;
Dosing and Administration
Solution Aruthymol, according to the instructions, should be instilled into the conjunctival sac of the affected eye, 1 drop twice a day. The specific dosage, i.e. which drug to use - 0.25% or 0.5%, is determined by the attending physician, taking into account the type of disease and the severity of its course.
After stabilization of intraocular pressure, the number of instillations should be reduced to 1 per day.
Arutymol is intended for long-term use.
In most cases, Arutymol, according to reviews, is well tolerated, but in some cases it has side effects. They can manifest themselves in the form of:
- Hyperemia and irritation of the conjunctiva and skin of the eyelids, burning and itching in the eyes, edema of the corneal epithelium, photophobia, lacrimation, diplopia, dry eye, ptosis, corneal hypoesthesia, superficial punctal keratopathy (from the organ of vision);
- Heart failure, AV blockade, lowering blood pressure, bradyarrhythmias, bradycardia, collapse, transient cerebrovascular accident, cardiac arrest (from the cardiovascular system);
- Headache, weakness, paresthesia, dizziness, depression (from the peripheral and central nervous system);
- Dyspnea, pulmonary insufficiency, bronchospasm (on the part of the respiratory system);
- Nausea and diarrhea (on the part of the digestive system);
- Eczema and urticaria (allergic reactions).
Also Arutimol, according to reviews, can cause alopecia, rhinitis, sexual dysfunction, in newborns - apnea.
In the postoperative period after fistulizing antiglaucoma surgery on the background of Arutymol application, retinal detachment is possible.
Each patient undergoing Aruthymol treatment should regularly visit the attending physician to measure intraocular pressure and cornea examination.
During the use of this drug should not wear soft contact lenses, because benzalkonium chloride, which is part of Arutymol as a preservative, can be deposited in them and have an adverse effect on eye tissue. In the event that a person wears hard contact lenses, they should be removed before instillation and installed no earlier than 15 minutes later.
People who will have surgery with general anesthesia should warn their doctor that they are being treated with Arutimol - it should be canceled 48 hours before the upcoming surgery.
Immediately after the solution is instilled, it is possible to slow down the reaction rate and decrease the clarity of vision, and therefore caution should be exercised by people driving a car or performing potentially dangerous tasks for 30-60 minutes after instillation of the drug. The described negative effects are enhanced by the simultaneous use of ethanol, therefore, during the period of application of Arutymol, it is necessary to refrain from alcohol-containing beverages.
The decrease in intraocular pressure increases with the simultaneous use of eye drops containing epinephrine (adrenaline), which, by the way, can cause pupil dilation.
It is not recommended to simultaneously use Arutimol with beta-blockers, calcium channel blockers and reserpine, since such a combination can lead to slower heart rate and lower blood pressure.
Patients using muscle relaxants should be aware that timolol enhances their action.
With simultaneous use of Arutimol with oral hypoglycemic agents and insulin, hypoglycemia may develop.
The following drugs are analogues of Arutymol:
- According to the active substance: Glautam, Niolol, Okucher, Okumed, Okumol, Okupres-E, Oftan, Timadren, TioGhexal, Timolol, Timolol-Betalek, Tipollong, Oftan Timogel;
- According to the mechanism of action: Azarga, Anaprilin, Betaxolol, EU Betalmik, Betoptik, Beofthan, Hanforth, Duoprost, DuoTrav, Combigan, Xalák, Xonef, Xonéf BC.
Terms and conditions of storage
Arutimol is a preparation of List B, which should be stored in a cool place (where the air temperature does not exceed 25 ºС), dry and protected from sunlight. Its shelf life is 3 years, after opening the bottle - a maximum of 6 weeks.