Artezin is an antihypertensive drug, alpha1-blocker, also used for urination disorders in benign prostatic hyperplasia.
Release form and composition
Make Artezin tablets containing 1, 2 or 4 mg of doxazosin each.
Auxiliary components of the drug are: lactose, potato starch, microcrystalline cellulose, colloidal silicon dioxide, povidone, magnesium stearate, sodium lauryl sulfate.
10 tablets in blister packs.
Indications for use
According to the instructions, Artezin is indicated for:
- Hypertension. The drug is used as monotherapy or as part of a combined treatment with beta-blockers, other antihypertensive drugs, thiazide diuretics, ACE inhibitors and slow calcium channel blockers;
- Benign prostatic hyperplasia (as with normal blood pressure, and in the presence of hypertension).
According to the instructions, Artezin is not used in the following cases:
- Age up to 18 years (tablets of 2 and 4 mg), since safety and efficacy have not been established;
- Hypersensitivity to doxazosin, quinazolone derivatives and auxiliary components of the drug.
In applying Artezin caution should be exercised when:
- Aortic and mitral stenosis;
- Orthostatic hypotension;
- Under 18 years old (for 1 mg tablets);
- Impaired liver function.
Dosing and Administration
Artezin is intended for internal use, regardless of the meal, the recommended time - 1 time per day, morning or evening.
The initial daily dosage of medication for hypertension is 1 mg - in the evening before bedtime. After taking the first dose, the patient should lie in bed for 6-8 hours. This will prevent the possible development of the “first dose phenomenon”, especially if the patient had previously taken thiazide diuretics.
If, after 1-2 weeks after the start of Artezin, a sufficient therapeutic effect is not observed, an increase in the dosage to 2 mg is allowed, followed by an increase of another 2 mg over the course of 1-2 weeks.
Most patients note the optimal therapeutic effect of Artezin with a daily dose of 8 mg. The maximum daily dose should not exceed 16 mg.
Upon reaching the optimal therapeutic effect, the dose of the drug is gradually reduced, reaching 2-4 mg per day.
The initial dose of Artezin for benign prostatic hyperplasia is 1 mg per day. If necessary, increase the dose to 2-4 mg per day. The maximum daily dose of Artezin should not exceed 8 mg.
The duration of Artezin therapy is individual and is determined by the attending physician.
If Artezin is used in high doses, overdose symptoms may develop:
- A pronounced decrease in blood pressure;
In the event of an overdose, the patient should take a horizontal position, lifting his legs up, to carry out symptomatic treatment.
In the treatment of hypertension, the following side effects of Artezin may occur:
- Central and peripheral nervous systems: headache, dizziness, drowsiness;
- Cardiovascular system: fainting, edema, tachycardia, bradycardia, chest pain, angina pectoris, myocardial infarction, arrhythmia;
- Respiratory system: rhinitis;
- Digestive system: nausea;
- Other side effects: malaise, fatigue, asthenia.
According to the instructions, Artezin in the treatment of benign prostatic hyperplasia can cause the following adverse reactions:
- Cardiovascular system: orthostatic hypertension, lowering blood pressure;
- Central and peripheral nervous systems: hypesthesia, priapism, dry mouth, tremor, insomnia, paresthesia, irritability;
- Endocrine system: gynecomastia;
- Blood system: purpura, leukopenia, thrombocytopenia;
- Digestive system: constipation or diarrhea, flatulence, abdominal pain, dyspepsia, increased liver enzymes, jaundice, cholestasis, hepatitis, loss of appetite;
- Sense organs: tinnitus, blurred vision;
- Skin reactions: hair loss;
- Respiratory system: shortness of breath, cough, bronchospasm, bleeding from the nose;
- Urinary system: hematuria, polyuria, urinary incontinence, dysuria, urination disorders;
- Allergies: skin rash, urticaria;
- Other side effects: flushing of the skin of the face, back pain.
In the appointment of Artezin patients with impaired liver function should be especially careful, especially in combination with drugs that adversely affect liver function. At the slightest signs of deterioration in the functional state of the liver, Artezin should be discontinued.
In order to prevent unwanted orthostatic reactions, patients should avoid abrupt changes in body position.
Before starting Artezin treatment, it is necessary to make sure that the patient does not have a malignant prostate tumor.
It is undesirable to take alcoholic beverages during Artezin treatment, as this may aggravate the side effects of the medication.
Since Artezin can cause orthostatic reactions at the beginning of therapy, it is recommended that patients refrain from controlling potentially dangerous mechanisms.
Despite the fact that Artezin does not have embryotoxic and teratogenic effects, during pregnancy and breastfeeding, it should be prescribed only after a careful balance of risks for the fetus or infant and the expected benefits for the mother.
The following drugs are analogues of Artezin:
- Kardura Neo.
Terms and conditions of storage
Artezin belongs to the list B. The medicine should be stored out of the reach of children, protected from moisture and light. Shelf life - 3 years.