Arifon is an antihypertensive drug.
Release form and composition
Arifon tablets are made, the active component of which is indapamide (2.5 mg in 1 tablet).
Auxiliary substances of the drug are lactose monohydrate, magnesium stearate, talc, povidone, corn starch.
Indications for use
According to the instructions, Arifon is indicated for the treatment of hypertension, as well as sodium and water retention in chronic heart failure.
According to the instructions, Arifon should not be used when:
- Hypersensitivity to indapamide or auxiliary components of the drug;
- Hepatic encephalopathy;
- Severe renal failure.
The simultaneous use of Arifon and drugs that prolong the QT interval is contraindicated.
Dosing and Administration
Arifon tablets are intended for internal use. The standard dosage is 2.5 mg once daily (preferably in the morning).
If during two weeks after the start of therapy with Arifon there is an insufficient hypotensive effect, an increase in the dosage to 5-7.5 mg per day is allowed.
The maximum daily dose is 10 mg (divided into two doses).
According to the instructions, indapamide, even in high concentrations (up to 40 mg), does not produce a toxic effect.
In case of overdose of Arifon the following symptoms are possible:
- Violation of water and electrolyte balance (hypokalemia, hyponatremia);
- Confusion of consciousness;
- Oliguria or polyuria;
- Nausea and vomiting;
When overdose symptoms appear, urgent measures should be taken to remove indapamide from the body: gastric lavage, taking adsorbents, restoring water and electrolyte balance.
The use of Arifon can cause the following side effects:
- Central nervous system: dizziness, fatigue, weakness, nervousness;
- The digestive system: pain and discomfort in the epigastrium, nausea;
- Cardiovascular system: orthostatic hypotension;
- Metabolism: hyperuricemia, hypokalemia, hyperglycemia, hypochloremia, hyponatremia;
- Allergies: skin reactions.
According to the instructions, Arifon is not recommended for use during pregnancy, even if physiological edema is observed. Diuretics can cause placental ischemia, which leads to impaired fetal development.
The active ingredient of Arifon - indapamide - is excreted in breast milk, so the use of medication during breastfeeding is not recommended. If necessary, therapy with Arifon should stop breastfeeding.
When prescribing Arifon, patients with diabetes should monitor their blood glucose levels.
The use of Arifon in patients with a high content of uric acid may cause an increase in gout attacks.
In case of liver failure, taking the drug may cause the development of hepatic encephalopathy. If this is observed, the reception of Arifon should be canceled.
Patients should be aware that at the beginning of Arifon’s therapy, a decrease in glomerular filtration may be observed, which is due to hypovolemia due to the loss of sodium ions and water during diuretic therapy. As a result, this leads to an increase in creatinine and urea levels. With normal kidney function, temporary renal failure quickly and completely passes.
During treatment with Arifon, exacerbation of disseminated lupus erythematosus may be observed.
Before starting drug therapy, it is recommended to know the level of sodium ions in the blood plasma. Throughout the treatment, this indicator should be monitored, especially for elderly patients with cirrhosis of the liver.
In the case of the development of hypokalemia during the treatment with Arifon, it is recommended to prescribe an appropriate treatment.
Before starting the study of the function of the parathyroid glands, the intake of Arifon and other diuretics should be canceled.
If there is a need simultaneously with the use of Arifon prescribing laxatives, preference should be given to drugs that do not affect intestinal motility.
Against the background of treatment with indapamide, a positive test for doping among athletes is not excluded.
Arifon is not prescribed to children and adolescents under the age of 18, as there is no clinical experience in the use of medication for this age group.
Arifon does not affect the ability to control vehicles and other means that require high concentration of attention.
Analogues of Arifon are the following drugs:
- Indapamide Nycomed;
- Ravel CP;
Terms and conditions of storage
Arifon should be stored in a dry, dark place out of the reach of children. Shelf life - 5 years.