Argosulfan is an antibacterial drug intended for external use.
Release form and composition
The only form of drug release is 2% cream. It is a homogeneous soft mass of white or white-pink color.
The main active component of Arogosulfan is silver sulfate, the content of which in 1 g of cream is 20 mg. In addition, as auxiliary substances are presented:
- 84.125 mg cetostearyl alcohol (combination of 40% stearyl and 60% cetyl alcohols);
- 20 mg of liquid paraffin;
- 75.9 mg of white petrolatum;
- 53.3 mg glycerol;
- 10 mg of sodium lauryl sulfate;
- 0.66 mg methylhydroxybenzoate;
- 0.33 mg of propyl hydroxybenzoate;
- 1.178 mg of potassium dihydrogen phosphate;
- 13.052 sodium hydrogen phosphate;
- Less than 1 g of water for injection.
The cream is packaged in aluminum tubes of 15 or 40 mg. Tubes are located in cardboard packs.
Indications for use
The use of Argosulfan is recommended for burns of varying severity and different genesis (including thermal, solar, radiation, chemical, caused by exposure to electric current and others), as well as frostbite.
In addition, Argosulfan is effective in the treatment of pressure ulcers, trophic ulcers of the legs, including those caused by chronic venous insufficiency, blood supply disorders in diabetes mellitus, erysipelas and obliterative endarteritis.
It is advisable to use the cream in the treatment of purulent wounds, minor household injuries (cuts and abrasions), infected dermatitis, complicated impetigo, microbial eczema, streptostaphyloderma, simple contact dermatitis.
As indicated in the instructions for Argosulfan, the drug is not recommended for use in patients with congenital insufficiency of glucose-6-phosphate dehydrogenase, with hypersensitivity to sulfonamides in general and sulfathiazole in particular. Also, a contraindication to the use of the cream is prematurity and age less than 2 months, since there is a high risk of developing “nuclear” jaundice.
Dosing and Administration
Argosulfan should be applied externally, topically. It is possible to use both in the form of occlusive dressings and in the open way.
On a wound that has been cleaned and surgically treated under sterile conditions, it is necessary to apply a layer of cream with a thickness of 2-3 mm from 2 to 3 times per day. It is necessary, if necessary, to repeat the procedure in such a way that the entire wound is constantly covered with a layer of cream.
It is recommended to apply Argosulfan until full restoration of damaged skin or until skin grafting.
If an exudate appears as a result of applying the cream, it is necessary to wash the wound with an antiseptic (for example, 0.1% aqueous chlorhexidine solution) before re-treating the wound.
The maximum allowable daily dose is 25 g; The maximum duration of therapy is 60 days.
In some cases, the use of Argosulfan is fraught with the appearance of skin-allergic reactions, irritation or burning sensation at the site of application of the drug. Prolonged use of the cream can lead to changes in the blood-forming organs, characteristic of sulfonamides, and the appearance of desquamative dermatitis.
Patients with renal or hepatic insufficiency are recommended to control the concentration of sulfathiazole in the blood during Argosulfan.
Appointment of Argosulfan to patients who are in a state of shock or with extensive burns should be made with caution, due to the inability to collect a full allergological history.
Argosulfan does not affect the ability to control complex mechanisms.
Analogues of the drug are the drugs presented below:
- Mafenida acetate;
- Ebermin et al.
Terms and conditions of storage
The shelf life of the drug, as indicated in the instructions for Argosulfan, is 24 months.
Store the medication at a temperature not higher than 25 degrees. Keep the drug out of the reach of children. Do not freeze.