Angelica - anti-menopausal drug.
Release form and composition
Angelica is available as a film-coated grayish-pink tablet, each containing:
- 1 mg of estradiol (in the form of hemihydrate);
- 2 mg of drospirenone;
- Excipients such as corn starch, lactose monohydrate, magnesium stearate, pregelatinized corn starch, talc, macrogol, hypromellose, titanium dioxide, povidone K25, macrogol 6000, iron dye red oxide.
Angelica tablets are sold in blisters of 28 pieces, packed in cardboard boxes.
Indications for use
The instructions to Angelica stated that this drug is prescribed:
- As hormone replacement therapy for menopausal disorders in the postmenopausal period;
- For the prevention of postmenopausal osteoporosis.
According to the annotation to the drug, the use of Angelica is contraindicated in:
- Vaginal bleeding of unknown etiology;
- Breast cancer or suspicion of it;
- Hormone-dependent precancerous disease;
- Hormone-dependent malignant tumors;
- Severe liver disease;
- Liver tumors, including a history;
- Acute arterial thrombosis;
- Severe kidney disease, including a history of;
- Acute renal failure;
- Exacerbation of deep vein thrombosis;
- Venous thromboembolism, in history including;
- Severe hypertriglyceridemia;
- The presence of a high risk of venous or arterial thrombosis;
- Congenital lactase deficiency;
- Glucose-galactose malabsorption;
- Lactose intolerance;
- The presence of hypersensitivity to any component of the drug;
It is possible to use Angelica, but with great care and under constant medical supervision with:
- Congenital hyperbilirubinemia;
- Cholestatic jaundice;
- Myome of the uterus;
- Cholestatic itch during pregnancy in history;
- Diabetes mellitus.
Also, estrogens (both separately and in combination with gestagens) should be used with caution in such diseases and conditions as:
- Retinal thrombosis;
- Systemic lupus erythematosus;
- Moderate hypertriglyceridemia;
- Diseases of the gallbladder;
- Edema in chronic heart failure;
- Bronchial asthma;
- Severe hypocalcemia;
- Hepatic hemangiomas;
- Conditions that can lead to the development of hyperkalemia;
- Medication that can cause hyperkalemia (angiotensin II receptor antagonists, potassium-saving diuretics, ACE inhibitors, heparin, potassium drugs).
Dosing and Administration
If the woman at the time of the start of treatment Angelica did not take estrogens or switches to this drug from another combination medication intended for continuous use, she can start using Angelica at any time. Those patients who switch to this drug from a combination drug for cyclic hormone replacement therapy should begin treatment after the end of withdrawal bleeding.
The course is designed for a 28-day period - 1 tab. in a day. After the end of the pills, the next day you should start a new package of Angelique, it should be the same day of the week as for the first tablet from the previous package.
At what time of day to take the drug Angelique, does not matter, but it is desirable that every day it was the same time.
If, for some reason, the woman missed the next admission, she should take the next pill Angelique as soon as possible. But in the event that more than 24 hours have passed, you do not need to take an extra pill. If you skip a few pills, vaginal bleeding may develop.
Reviews indicate that Angelique can have side effects. Most often (more than 6% of patients) such adverse reactions occur:
- Stomach ache;
- Bleeding from the genital tract (in this case, the longer the treatment, the less bleeding occurs);
- Gastrointestinal pain;
- Soreness of the mammary glands.
Undesirable reactions when taking Angelica in order of decreasing severity:
- Often (in more than 1 case out of 10), there are: emotional lability, migraine, cervical polyp;
- Infrequently (more than 1 in 1000 women), there are: arterial and venous thromboembolic complications (thrombosis and embolism, occlusion of peripheral deep veins, myocardial infarction, stroke, cerebral infarction), breast cancer.
After a very long period after the start of taking Angelica, or in isolated cases, the following side effects may occur:
- Liver tumor;
- Hormone-dependent precancerous or malignant tumors;
- Endometrial cancer;
- Impaired liver function;
- Arterial hypertension;
- Reactivation of endometriosis;
- Increasing the size of uterine fibroids;
- Change in glucose tolerance;
- Jaundice or itching associated with cholestasis;
In hereditary angioedema, exogenous estrogens, including Angelica, can cause exacerbation of symptoms.
Also when using Angelica, according to reviews, allergic reactions due to hypersensitivity to one or another of its components are possible.
The hormonal drug Angelica is not intended to be used for contraception.
Analogues of Angelica are the following drugs: Aktel, Indivina, Klimodien, Kliogest, Pausogest, Revmelyd, Trisequens, Femoston, Evian.
Terms and conditions of storage
Angelique, according to the instructions, can be stored for 5 years in a dry place at temperatures up to 25 ºС.