Antisten

Antisten is an antihypoxic drug that improves the metabolism of neurosensory organs and the myocardium in ischemia.

Release form and composition

The medicine is produced in the form of Antisten tablets, each of which contains 20 mg of trimetazidine dihydrochloride, and tablets of the prolonged action of Antisten MV, containing 35 mg of the active substance.

Auxiliary components used in the manufacture of medicines: hypromellose, magnesium stearate, colloidal silicon dioxide, microcrystalline cellulose.

Polyvinyl alcohol, titanium dioxide, macrogol, and iron dyes red and yellow oxides are included in the film of Antisten MV film.

Indications for use

As indicated in the instructions for Antisten, this drug is intended for:

• Long-term treatment of coronary heart disease, in particular for the prevention of strokes;
• Treatment of cochleovestibular disorders of ischemic origin, including hearing impairment, tinnitus, dizziness, etc .;
• Therapy of chorioretinal vascular disorders with ischemic component.

Contraindications

According to the annotation to the drug, the use of Antisten is contraindicated:

• In the presence of hypersensitivity to trimetazidine or any auxiliary component of the drug;
• Patients with renal failure, if the CC is less than 15 ml per minute;
• Patients with severe liver dysfunction;
• Children and adolescents under 18 years of age (due to the lack of sufficient data on the safety of the drug in this age group of patients);
• Pregnant women;
• During lactation.

Dosing and Administration

Antisten tablets, according to the instructions prescribed in a daily dose of 40-60 mg, divided into 2-3 doses, Antisten MV - 1 tab. twice a day with an interval of 12 hours.

It is necessary to take medicine during food, washing down with enough water.

The doctor determines the duration of therapy individually for each patient depending on the clinical situation.

Side effects

According to reviews of patients who have undergone anti-stenosis treatment, in the overwhelming majority of cases this antihypoxant drug is well tolerated and does not have any side effects if the dosage regimen recommended by the doctor is observed. However, it should be noted that in some cases undesirable reactions on the part of the body are observed:

• Relatively often: nausea, dyspepsia, vomiting, diarrhea, abdominal pain, dizziness, asthenia, headache;
• Rarely: flushing to the skin of the face, orthostatic hypotension;
• Very rarely: reversible extrapyramidal disorders, manifested by rigidity, tremor and akinesia.

Also Antisten, according to reviews, can cause allergic reactions due to hypersensitivity or intolerance to one or another component of the drug.

Cases of overdose with this drug have not been registered in medical practice today.

special instructions

Studies using trimetazidine dihydrochloride, conducted on animals, did not reveal a teratogenic effect, but there is no clinical experience of taking the drug in pregnant women, and therefore the risk of any developmental abnormalities in the fetus cannot be excluded. For this reason, it is not recommended to prescribe Antisten during pregnancy.

Whether trimetazidine is excreted in breast milk has not been established. If you need to undergo a course of treatment with Antisten during lactation, you should consult with your doctor about whether to stop feeding.

Antisten is prescribed for the prevention of angina attacks, but it is not intended for stopping them! Also, this drug is not indicated for the initial course of treatment of myocardial infarction or unstable angina.

If a patient suffers a stroke at the time of using Antisten, the course of therapy should be reviewed.

If, for some reason, the next missed pill was missed, doubling the dose at the next dose is prohibited!

Significant impact on the ability to drive and perform other potentially dangerous activities, subject to the dosage recommended by the doctor, the drug does not have.

Analogs

The following drugs are analogues of Antisten:

• According to the active substance: Angiosil Retard, Vero-Trimetazidine, Deprenorm, Carditrim, Medarum, Metagard, Predisin, Precardum, Preductal, Rimecor, Trimektal, Trimetta, Trimetazid, Trimetazidine, Tridukard;
• According to belonging to the same pharmacological group and mechanism of action: Biosynth, Boyrashniy-Alkoy, Hawthorn tincture, Vasomag, Dibikor, Doppelgerts Cardiovital, Esafosfina solution, Idrinol, Inosie-F, Cardionat, Coraxan, Coronaterra, Kudewita, Cudesser, Idrin. , Mildronat, Neoton, Orokamag, Pedea, Riboxin, Serotonin, Tauphon, Ubinon, Firazir, Fostaden.

Terms and conditions of storage

Antisten - a drug belonging to the list B and released from pharmacies only by prescription of the attending physician. Its shelf life is 3 years, provided that the storage rules recommended by the manufacturer are kept cool (where the air temperature does not exceed 25 ºС), dry, protected from sunlight and inaccessible to children.