Anaprilin is a drug with antihypertensive, antiarrhythmic and antianginal properties.
Release form and composition
The drug is available in the form of tablets and solution for IV injection, the main active ingredient of which is propranolol. In one pill its content reaches 40 mg.
The following ingredients are added to the tablets: calcium stearate, milk sugar, potato starch, talc.
Tablets are located in blisters in the amount of 10 or 20 pieces. A carton pack contains 5 or 10 cells. In addition, Anaprilin in the amount of 100 tablets can be packaged in a dark glass jar, located in a cardboard box.
Indications for use
The use of Anaprilina is effective in the treatment of arterial hypertension, angina pectoris and unstable stenocardia, sinusitis, anaphyctonia, supraventricular tachycardia, tachysystolic form of atrial fibrillation, essential tremor, ventricular and supraventricular extrasystoles, and alcohol withdrawal (especially in case of incense). ), diffuse toxic goiter, thyrotoxic crisis. It is also advisable to use a drug for the prevention of migraine.
It is recommended to refuse treatment with Anaprilin if a patient has AV 2 and 3 degree blockade, sinoatrial blockade, bradycardia, SSS, hypotension, chronic 2B-3 stage failure, acute heart failure, cardiogenic shock, hypersensitivity to the main component of Anaprilin .
Dosing and Administration
Dosing regimen is selected individually.
The drug should be taken orally, regardless of the time of the meal.
In the instructions for Anaprilin, the recommended dosage for the treatment of arterial hypertension is 40 mg twice a day. It is allowed to increase the dose in the absence of a pronounced effect up to 40 mg three times a day or 80 mg each - twice. It is not recommended to exceed the maximum recommended dosage per day: 320 mg (in exceptional cases it is 640 mg).
Treatment of angina pectoris and heart rhythm disorders is carried out by using Anaprilin in an amount of 20 mg three times a day. The dose is gradually increased to 80-120 mg, which should be divided into 2-3 doses. The maximum daily dose of Anaprilina in this case is 240 mg.
In the prevention of migraine and in the treatment of essential tremor, it is recommended to take Anaprilina in the amount of 40 mg two or three times a day (initial dose), then increase the dosage to 160 mg per day.
With the on / in the introduction of the drug, the recommended initial dose is 20 mg, one-time - from 40 to 80 mg, the frequency per day - no more than 3 times.
The use of Anaprilina in some cases is fraught with the occurrence of undesirable reactions from peripheral NS and the central nervous system, in particular: weakness, headache, increased fatigue, dizziness, insomnia, depression, drowsiness, vivid dreams, confusion, tremor, hallucinations, anxiety, nervousness.
It is also possible the appearance of sinus bradycardia, AV-blockade (which may entail a complete transverse blockade or cardiac arrest), arrhythmias, orthostatic hypotension, angiospasm, chest pain and the development of chronic heart failure.
Among the changes in the work of the senses can be observed soreness and dryness of the eyes.
On the part of the digestive system, in some cases, nausea, vomiting, diarrhea or constipation, pain in the epigastric region, abnormal liver function, as well as changes in taste and increased activity of hepatic transaminases are noted.
Possible nasal congestion, bronchospasm.
In some cases, as noted in the instructions for Anaprilin, the occurrence of thrombocytopenia, leukopenia is likely.
There may be a change in the concentration of glucose in the blood.
It is also possible to increase sweating, the occurrence of psoriasis reactions, exacerbation of symptoms of psoriasis, the appearance of skin rash, itching, urticaria.
Among other adverse reactions to anaprilin: arthralgia, withdrawal syndrome, back pain, decreased potency.
The use of Anaprilina by groups of patients listed below is allowed, however, it requires caution: persons with asthma, bronchitis, diabetes mellitus, decompensated heart failure, renal or hepatic insufficiency, depression, myasthenia, psoriasis, occlusive peripheral vascular diseases, as well as elderly people who are pregnant women, women in the period of lactation, children.
In some cases, during the treatment, the symptoms of psoriasis are exacerbated.
Cancellation of the drug after a long course of treatment is possible only under medical supervision, gradually.
Against the background of treatment with Anaprilin, it was recommended to refuse intravenous administration of diltiazem and verapamil.
If you need anesthesia, taking Anapralina is stopped in advance, or funds are selected, the negative inotropic actions of which are minimal.
It should be individually assessed the possibility of using the drug by persons whose activity is connected with the need to manage complex mechanisms.
The following are analogues Anaprilina:
- Timolol and others
Terms and conditions of storage
Store the drug should be no more than 4 years in a dry, dark place, out of the reach of children.