Anafranil is an antidepressant.
Release form and composition
- Anafranil with the content of the active substance - clomipramine hydrochloride - in the amount of 25 mg;
- Anafranil CP with clomipramine hydrochloride 75 mg.
In blister packs of 10 tablets.
Indications for use
According to the instructions, Anafranil prescribed adults in the following cases:
- Depression (endogenous, reactive, neurotic, masked, organic, involutional), depression in patients with schizophrenia and psychopathy, depressive senile syndromes;
- Chronic pain syndrome;
- Obsessive-compulsive syndrome;
- Cataplexy associated with narcolepsy;
- Panic attacks and phobias.
Children and adolescents Anafranil prescribed for:
- Nocturnal enuresis (only after 5 years of age and subject to the exclusion of organic causes of enuresis);
- Obsessive-compulsive syndrome.
According to the instructions, Anafranil is contraindicated in:
- The presence of hypersensitivity to the active or auxiliary components of the drug, as well as increased sensitivity to tricyclic antidepressants of the dibenzazepine group;
- Simultaneous use of MAO inhibitors, as well as 2 weeks before and after their use;
- Concurrent use with inhibitors of MAO type A reversible action;
- Recent myocardial infarction;
- Congenital long QT syndrome.
During pregnancy and breastfeeding the use of Anafranil is not recommended, except for the vital indications for it.
Do not prescribe medication to children whose age has not reached 5 years, as no study of the effect of the drug on this age group has been conducted.
Dosing and Administration
The dosage Anafranila selected individually, depending on the patient's condition. The main task of treatment is to achieve the optimal therapeutic effect with the use of the lowest possible dosages of the drug.
Before starting to use Anafranil, hypokalemia should be eliminated if it is present.
When obsessive-compulsive syndrome, depression, phobias Anafranil prescribed in a dose of 25 mg three times a day or 75 mg once a day. Every few days, the dose of the drug is increased by 25 mg to achieve the optimum, which is 100-150 mg per day.
In severe cases, dosage can be increased to 250 mg. After reaching the desired therapeutic effect of the patient is transferred to a maintenance dose of 50-100 mg per day.
With agoraphobia, panic disorder, the dose of Anafranil at the initial stage is 10 mg per day with a gradual increase, depending on the patient's tolerance, to 25-100 mg. The recommended treatment time is six months.
With cataplexy, concomitant narcolepsy, the dosage of Anafranil is 25-75 mg per day.
In chronic pain syndrome, the dosage of the drug depends on the severity of the symptoms and varies from 10-150 mg per day.
Elderly patients Anafranil prescribed in an initial dose of 10 mg per day with a gradual increase over 10 days to 30-50 mg.
The use of Anafranil may cause the following side effects:
- Central and peripheral nervous systems: fatigue, drowsiness, increased appetite, anxiety, disorientation, confusion, hallucinations, agitation, anxiety, depersonalization, manic condition, tremor, headache, delirium, paresthesia, increased muscle tone, ataxia, convulsions;
- Cardiovascular system: palpitations, sinus tachycardia, orthostatic hypotension, increased blood pressure, arrhythmias, minor ECG changes, intracardiac conduction disturbances;
- Digestive system: nausea, vomiting, diarrhea, abdominal discomfort, anorexia, hepatitis, increased levels of liver enzymes;
- Skin reactions: skin allergies (photosensitivity, urticaria, rash, itching), edema, alopecia;
- Endocrine system: impaired potency and libido, weight gain, breast swelling, galactorrhea, inappropriate antidiuretic hormone response syndrome;
- Hematopoietic system: agranulocytosis, leukopenia, thrombocytopenia, eosinophilia, purpura;
- Hypersensitivity reactions: systemic anaphylactoid reactions, allergic alveolitis with or without eosinophilia;
- Sense organs: tinnitus, impaired taste;
It is known that tricyclic antidepressants can reduce the threshold of convulsive readiness, therefore, patients with epilepsy should be careful in the use of Anafranil.
Caution in taking Anafranil should also be observed in patients with cardiovascular diseases, especially with cardiovascular insufficiency, arrhythmias, and intracardiac conduction disorders. If it is necessary to take Anafranil, these patients should monitor the performance of the heart.
Before starting treatment, blood pressure should be measured, since a sharp decrease in pressure cannot be excluded, especially in patients with orthostatic hypotension and cardiovascular lability.
Anafranil 25 mg contains sucrose and lactose, so it should not be taken in patients with rare hereditary diseases (fructose and galactose intolerance, lack of lactase, sucrose-isomaltase deficiency).
Alcohol can increase undesirable side effects of Anafranil on the part of the central nervous system, such as drowsiness, blurred vision.
It is not recommended to administer potentially dangerous mechanisms that require increased concentration of attention during the use of the drug.
Analogues of Anafranil are the following drugs:
Terms and conditions of storage
According to the instructions, Anafranil should be stored in a cool place out of reach of children. Shelf life of the drug is 5 years.