Ampiside is a broad-spectrum antibacterial agent.
Release form and composition
The drug is available in the form of tablets and powder.
One tablet of ampisida contains 375 mg of sultamicillin. They are covered with a film shell, in an amount of 10 pieces are packed in dark glass bottles. Vials are located in cartons.
The main active ingredients of the powder are ampicillin and sulbactam.
The powder is of two types: for the preparation of suspensions for oral administration and for the manufacture of a solution for intramuscular and intravenous administration. In the first case Ampisid 250 ml volume is packed in a bottle of dark glass. In the second case, a powder containing ampicillin in the amount of 500 mg and sulbactam weighing 250 mg comes complete with water for the preparation of injections (1.8 ml). At the same time, Ampisid is packaged in vials and the solvent in ampoules.
Indications for use
Ampiside use is recommended for the treatment of bacterial infections caused by susceptible microorganisms. In particular, the drug is effective in infections:
- Respiratory, including lung abscess, pleural empyema, chronic bronchitis, pneumonia;
- ENT organs, including sinusitis, otitis media, tonsillitis;
- Genital organs and urinary tract, including cystitis, pyelitis, pyelonephritis, endometritis;
- Biliary tract, including cholangitis and cholecystitis;
- Soft tissues and skin, including erysipelas, secondarily infected dermatitis, impetigo;
- Gastrointestinal tract, including dysentery, salmonellosis;
- Bones and joints.
In addition, the use of the drug is advisable in the treatment of septic endocarditis, sepsis, meningitis, peritonitis, scarlet fever, gonococcal infection, and also as a prophylaxis of postoperative complications during operations on the pelvic organs and the abdominal cavity.
According to the instructions to Ampisid, the use of the drug is not recommended for persons with infectious mononucleosis, with hypersensitivity to the components of the drug, as well as for women during lactation.
It is important to keep in mind that patients with renal or hepatic insufficiency and pregnant women do not use Ampisid contraindicated, but treatment should be carried out with caution.
Dosing and Administration
With oral medication for adults and children weighing more than 30 kg, 375-750 mg of ampisid is prescribed per day. For children weighing less than 30 kg, the daily dose is between 25 and 50 mg per kg of body weight. Frequency of admission - twice a day. The course of treatment lasts from 5 days to 2 weeks.
With drip in / in the introduction of the recommended rate of 60-80 drops per minute, with a jet - slow speed, from 3 to 5 minutes.
The duration of the course in / in the introduction is from 5 to 7 days. After that, if the need remains for the use of Ampisid, the drug is administered in / m.
Below are the total dosages of ampicillin and sulbactam (in a 2: 1 ratio).
In the case of a mild infection, 1.5 to 3 g of the drug is administered in 2 divided doses; in the case of moderate flow - from 3 to 6 g per day in 3-4 injections; in case of severe course - from 12 g per day in 3-4 injections.
Treatment of uncomplicated gonorrhea is carried out by introducing a single dose of 1.5 g.
Prevention of surgical infections is carried out by administering 1.5-3 g of the drug during anesthesia, after which, within a day after surgery, the same dose is administered every 6-8 hours.
Children Ampisid appointed in the amount calculated by the formula 150 mg per kg of body weight 3-4 times a day.
When treating premature babies and newborns younger than 1 week, the drug should be administered every 12 hours.
The duration of one course of application of Ampisides is from 5 to 14 days. If necessary, the duration of the course can be extended. After the temperature indicators return to normal, as well as after the disappearance of the pathological symptoms, the treatment should be continued for another two days.
Preparation of the solution for the / m and / in the introduction is carried out as needed. To do this, the contents of the vial are mixed with 2 or 4 ml of water for injection, 0.5% solution of procaine or 0.9% solution of sodium chloride. In addition, for the i / m introduction allowed dilution Ampisida 0.5% lidocaine solution. For iv administration, a single dose should be dissolved in a 5% dextrose solution or a 0.9% sodium chloride solution with a volume from 10 to 200 ml.
Undesirable reactions on the part of the digestive system, described in the instructions for Ampisid: vomiting, diarrhea, nausea, loss of appetite, increased "liver" transaminases, pseudomembranous enterocolitis.
On the part of the homeostasis system and the blood-forming organs, leukopenia, anemia, and thrombocytopenia can be observed.
Also on the background of the drug may cause drowsiness, malaise, headache.
In some cases, there is a change in laboratory parameters, in particular, azotemia, hypercreatinemia, and an increased concentration of urea may appear.
Sometimes there is the occurrence of allergic reactions, including skin flushing rhinitis, urticaria, conjunctivitis, arthralgia, fever, angioedema, eosinophilia, anaphylactic shock.
When i / m administration may appear soreness at the injection site, and with a / in - phlebitis.
Prolonged use of the drug can cause superinfection caused by pathogens resistant to the drug (candidiasis).
In patients with hypersensitivity to penicillins, allergic cross-reactions with cephalosporin antibiotics may occur.
During long-term treatment, constant monitoring of the state of the functions of the liver, kidneys, and blood-forming organs is necessary.
Therapy of patients with sepsis with Ampisis may cause the Jarish-Herxheimer reaction.
The following are the drugs, the composition and mechanism of action of which is similar to the composition and mechanism of action of Ampisides:
- Liklav and others.
Terms and conditions of storage
The drug should be stored no more than 2 years in a place protected from the penetration of light, where the temperature is not higher than 25 ° C.