Ampicillin is an antibiotic of a group of semisynthetic penicillins with a wide spectrum of action.
Release form and composition
The drug is available in the form of tablets, capsules, granules and powder. The active ingredient is ampicillin (as a trihydrate).
Indications for use
According to the instructions, Ampicillin is used for infectious diseases caused by pathogens that are susceptible to the active substance. This includes ENT infections, bronchopulmonary infections, gynecological infections, odontogenic infections, gastrointestinal infections, endocarditis, acute and chronic urinary tract infections, meningitis, sepsis, septicemia, rheumatism, infections of the skin and soft tissues, scarlet fever.
Contraindications to the use of ampicillin are lymphocytic leukemia, infectious mononucleosis, abnormal liver function and increased patient sensitivity to ampicillin and other penicillins.
Dosing and Administration
The dosage is set individually depending on the location of the infection, the severity of the treatment and the sensitivity of the pathogen to the drug. The duration of treatment may be different, it is determined by the characteristics of the course of the disease and the localization of the infection.
When taking Ampicillin orally a single dose for an adult is 250-500 mg, and the frequency of administration is 4 times a day. For intramuscular and intravenous administration, a single dose - 250-500 mg, every 4-6 hours.
The maximum daily dose for an adult is 4g when administered orally and 14 g for intramuscular and intravenous administration.
According to the instructions for ampicillin, its reception can lead to the following undesirable effects:
- On the part of the digestive system - nausea, vomiting;
- Allergic reactions - rhinitis, erythema, urticaria, angioedema, conjunctivitis, joint pain, fever, eosinophilia, anaphylactic shock.
Due to the chemotherapeutic effect of the drug, colitis, vaginal candidiasis and oral candidiasis may occur.
During treatment with ampicillin, liver and kidney function and peripheral blood should be systematically monitored. Patients with impaired renal function require dosage adjustment of the drug.
The use of ampicillin in high doses in patients with renal insufficiency can lead to toxic effects on the central nervous system. When using the drug in patients with bacteremia, the Jarish-Herxheimer reaction is possible (bacteriolysis reaction).
Analogues of this drug are drugs Zetsil and Standatsillin.
Terms and conditions of storage
The drug should be stored in a place protected from direct sunlight and out of reach of children at a temperature not exceeding 25 ° C. Do not freeze. Ampicillin has a shelf life of 3 years.