Amaryl is a hypoglycemic drug intended for oral use.
Release form and composition
Make Amaril tablets containing:
- 1 ml of glimepiride - pink;
- 2 ml glimepirida - green;
- 3 mg glimepiride - light yellow;
- 4 mg glimepiride - green.
In blisters 15 tablets each, 2 blisters per package.
Auxiliary components of Amaryl are: polyvidone 25000, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate.
According to the instructions, Amaryl is prescribed for type 2 diabetes mellitus as the main treatment or as part of a combination therapy in combination with insulin and metformin.
According to the instructions, Amaryl is contraindicated in the following cases:
- Type 1 diabetes;
- Severe abnormal liver function;
- Diabetic precoma and coma, diabetic ketoacidosis;
- Pregnancy and breastfeeding;
- Severe abnormal liver function (including patients on hemodialysis);
- Rare hereditary diseases (lack of lactase, galactose intolerance, glucose-galactose malabsorption);
- Hypersensitivity to the active or auxiliary components of the drug;
In the application of Amaril should be careful when:
- The presence of risk factors for hypoglycemia;
- Intercurrent diseases in the course of therapy or with a change in the patient's lifestyle (change in diet or meal times, decrease or increase in physical activity);
- Impaired absorption of food and drugs from the gastrointestinal tract (intestinal paresis, intestinal obstruction);
- Glucose-6-phosphate dehydrogenase deficiencies.
Dosage and Administration Amaril
The exact dosage of Amaril is determined on the basis of the initial blood glucose concentration.
Initially, the medication is prescribed in a minimum dose in order to achieve the desired metabolic control.
In the process of applying Amaryl, the patient should regularly monitor the level of glucose in the blood, as well as glycosylated hemoglobin.
Amaril tablets are taken whole with half a glass of water.
The initial dosage of Amaril is 1 mg per day. Increasing the dosage should be carried out gradually, with an interval of 1-2 weeks, in the following order 1 mg-2 mg-3 mg-4 mg-6 mg-8 mg per day.
As a rule, with well-regulated diabetes mellitus, the optimal dosage of Amaril is 1-4 mg. The use of Amaril in a dose of 6 mg or more per day is effective only for some groups of patients.
The frequency and time of application of Amaril is determined individually by the attending physician taking into account the age, severity of the disease, the patient's lifestyle, and the nature of the diet.
The daily dosage of Amaril should be taken at one time, mostly before breakfast or another meal. It is important not to skip meals after taking the pills.
In the process of applying Amaril, dosage adjustment may be necessary due to improved metabolic control. Amaril dose adjustment may also be required when:
- Lifestyle changes;
- Weight loss;
- The emergence of factors leading to the development of hyperglycemia or hypoglycemia.
According to the instructions, Amaril take a long time.
Side Effects of Amaril
Amaril can cause the following side effects from various systems of vital activity of the organism:
- Metabolism: hypoglycemia, the symptoms of which include fatigue, drowsiness, nausea, vomiting, headache, hunger, sleep disturbances, aggression, anxiety, depression, concentration disorders, speech disorders, confusion, visual disorders, cerebral seizures, bradycardia ;
- Visual organs: transient visual disturbances due to changes in blood glucose levels;
- Digestive system: abdominal pain, feeling of heaviness in the epigastrium, diarrhea, increased activity of liver enzymes, hepatitis, jaundice;
- The hematopoietic system: leukopenia, thrombocytopenia, erythrocytopenia, hemolytic anemia, agranulocytosis, pancytopenia, granulocytopenia;
- Allergies: skin rash, itching, urticaria, severe allergic reactions accompanied by shortness of breath, a sharp decrease in blood pressure, allergic vasculitis;
- Other adverse reactions: photosensitivity, hyponatremia.
At first the use of Amaril there is a high risk of hypoglycemia, so the patient must carefully monitor the level of glucose in the blood.
Glimepiride - the active component of Amaril - refers to sulfonylurea derivatives and can lead to the development of hemolytic anemia. Therefore, care should be taken when prescribing the drug to patients with glucose-6-phosphate dehydrogenase deficiency. It is preferable to prescribe such patients hypoglycemic agents that are not derived from sulfonylureas.
With the rapid intake of easily digestible carbohydrates, hypoglycemia can be promptly eliminated. However, for the reception of Amaril is characterized by the resumption of a stopped attack of hypoglycemia. Therefore, it is recommended that patients be kept under the supervision of doctors or relatives. In case of severe hypoglycemia, the patient must be taken to the hospital.
In the period of taking glimepirida should monitor the picture of peripheral blood and liver function of the patient.
Analogs of Amaril
The following drugs are related to Amaril analogues:
Terms and conditions of storage
According to the instructions, Amaryl refers to the list of drugs B, from pharmacies sold in the presence of a prescription.
Store the medicine in a dry, dark and out of reach of children for no longer than 3 years from the date of manufacture.