Alpha-tocopherol acetate (vitamin E) is a drug that has an antioxidant effect, is involved in cell proliferation, protein and heme biosynthesis, tissue respiration and other important processes of tissue metabolism, prevents increased capillary fragility and permeability of erythrocytes.
Release form and composition
The drug is available in the form of capsules and oil solution for ingestion and intramuscular injection.
Each capsule contains 100 mg of α-tocopherol acetate, in 1 ml of solution - 50, 100 or 300 mg of vitamin E.
Indications for use of alpha-tocopherol acetate
As indicated in the instructions for Alpha-tocopherol acetate, this vitamin preparation is prescribed for vitamin E and the increased body's need for vitamin E, including:
- Premature newborn;
- Young children with insufficient intake of this vitamin with food;
- With peripheral neuropathy;
- In diseases of the ligament apparatus and muscles;
- With abetalipoproteinemia;
- Patients with chronic cholestasis;
- Patients with cirrhosis of the liver;
- With gastrectomy;
- With atresia of the biliary tract;
- With Crohn's disease;
- Patients with obstructive jaundice;
- With celiac disease;
- With tropical sprue;
- Pregnant women (especially with multiple pregnancies);
- People with nicotine and drug addiction;
- During lactation;
- With necrotizing myopathy;
- With malabsorption;
- Persons taking drugs designed to reduce cholesterol intake from food;
- When taking mineral oils;
- People on a diet with a high content of polyunsaturated fatty acids;
- In the period of convalescence after the diseases that were accompanied by febrile syndrome;
- In old age;
- In post-infectious and post-traumatic myopathy;
- With high physical exertion;
- Women with climacteric autonomic disorders;
- With fatigue, neurasthenia;
- Patients with primary muscular dystrophy;
- People with degenerative and proliferative changes in the ligaments of the spine and joints;
- Men in violation of spermatogenesis and potency;
- With skin diseases;
- With epilepsy to increase the effectiveness of anticonvulsants.
Also, Alpha-tocopherol acetate, according to the instructions, is prescribed to children born with low body mass in order to prevent the development of bronchopulmonary dysplasia, hemolytic anemia, malabsorption and complications of retrolental fibroplasia (a serious disease affecting the retina of premature and low-weight children).
According to the annotation to the drug, the only contraindication to the use of alpha-tocopherol acetate is hypersensitivity.
With caution, vitamin should be taken by people with hypoprothrombinemia on the background of vitamin K deficiency, since when taking vitamin E in large doses (more than 400 IU) the disease can be exacerbated. Under constant observation, drug treatment should be carried out in patients with severe cardiosclerosis, an increased risk of thromboembolism and after myocardial infarction.
Administration and dosage of Alpha-tocopherol acetate
Alpha-tocopherol acetate capsules are taken orally, the solution is either taken orally or injected intramuscularly.
The specific dosage and duration of the use of vitamin determines the attending physician, taking into account the indications (prevention or treatment) and the severity of the patient's condition. As a rule, the daily dose ranges from 100 to 300 mg.
Side Effects of Alpha-Tocopherol Acetate
According to numerous reviews of people who have been treated with Alpha-tocopherol acetate, in the vast majority of cases the drug is well tolerated and does not cause any side effects if the dosage recommended by the doctor is observed. In extremely rare cases, allergic reactions may develop, which, as a rule, is due to hypersensitivity or intolerance to the drug. When administered intramuscularly, pain and infiltration may occur at the injection site. When taking a vitamin in high doses, pain in the epigastric region and diarrhea are possible.
With the simultaneous use of alpha-tocopherol acetate with cyclospony, the absorption of the latter increases, and with dicuramol and warfarin, their effects may change.
People on a diet that includes large amounts of sulfur-containing amino acids and selenium require a downward adjustment in the dose of vitamin E.
Alpha-tocopherol acetate enhances the effect:
- Nonsteroidal anti-inflammatory drugs;
- Vitamins A and D;
- Antiepileptic drugs, if there is an increased level of lipid peroxidation products in the patient's blood;
- Cardiac glycosides and also reduces their toxicity.
Vitamin A deficiency may occur when taking tocopherol in high doses.
With the simultaneous use of alpha-tocopherol acetate at a dosage of more than 400 IU per day with anticoagulants increases the risk of bleeding and hypoprothrombinemia.
Vitamin absorption is reduced by mineral oils, colestipol and colestiramine.
The need for vitamin E increases in people taking gland preparations, as they enhance the oxidative processes in the body.
Alpha-Tocopherol Acetate Analogs
Structural analogues of alpha-tocopherol acetate are Vitamin E, Vitrum Vitamin E, Enat, Evitol and Doppelgerts Vitamin E Forte.
Also α-tocopherol acetate is a part of a wide variety of vitamin complexes.
Terms and conditions of storage
From pharmacies, the drug is released without a doctor's prescription. Its shelf life is 2 years, subject to compliance with the storage guidelines recommended by the manufacturer - protected from direct sunlight, dry and cool (at a temperature of 15-25 ºС) place.