Albumin is a plasma-substituting substance that maintains oncotic blood pressure, contributes to an increase in blood pressure and bcc, compensates for the deficiency of plasma albumin. Also, the drug increases the reserves of protein nutrition of tissues and organs.
Release form and composition
Albumin is available in the form of a solution, solution for injection and solution for infusion. The main active substance is human albumin.
Indications for use of albumin
According to the instructions to Albumin, this drug is prescribed for the following diseases and conditions:
- Shock toxic, operative, purulent-septic, hemorrhagic, traumatic and hypovolemic;
- Nephrotic syndrome with nephritis;
- Hemolytic disease and hyperbilirubinemia in newborns;
- Hypoproteinemia and hypoalbuminemia;
- Severe burn, accompanied by dehydration and thickening of the blood;
- Liver disease with a violation of its albumin-synthesizing function;
- Medical plasmapheresis, hemodialysis;
- Diseases of the gastrointestinal tract, causing digestive disorders;
- Swelling of the brain;
- Acute respiratory distress syndrome in adults.
Albumin is also used in operations involving artificial blood circulation, as well as in the preparation of autologous blood components and preoperative hemodilution.
The drug is contraindicated in:
- Hypersensitivity to the active substance;
- Chronic anemia;
- Prolonged internal bleeding;
- Pulmonary edema;
- Chronic heart failure;
- Chronic renal failure;
Albumin is used with caution in suppressing heart function, as there is a risk of developing acute heart failure.
Dosing and Administration Albumin
Albumin is administered intravenously in a jet or drip way. The dose of the drug in each case is set individually, it depends on the evidence, clinical picture and the age of the patient. Most often it is 1-2 ml / kg of a 10% solution. The drug is applied daily or every other day, until the effect is noticed.
Before using Albumin, remove the film from the lid of the vial and treat it immediately with an antiseptic. It is important to carefully examine the drug: if it looks cloudy, has changed color or contains sediment, it is prohibited to use it.
Side effects of albumin
When using Albumin solution, side effects usually do not occur, but allergic reactions of varying severity are possible (urticaria, chills, fever, shortness of breath, anaphylactic shock, tachycardia, low blood pressure, pain in the lower back). They are prone to patients who are at risk, with intolerance to intravenous fluids, drugs, plasma substitutes, serums and vaccines.
If an allergic reaction or complication occurs, you should immediately stop the infusion of Albumin solution.
No experiments have been conducted to investigate the effect of this drug on reproductive function, so Albumin is carefully prescribed to pregnant women.
Analogues of this drug are Zenalb-20 and Plasmubin 20.
Terms and conditions of storage
According to the instructions, Albumin must be kept out of the reach of children, at room temperature. The shelf life of the drug is indicated on the package. After its expiration, the solution should not be used.