Aksamon belongs to the pharmacological group of cholinesterase inhibitors, intended for the treatment of diseases of the nervous system. Aksamon activates the transmission of neuromuscular impulses, improves the conductivity of excitation through the cells of smooth muscles and nerves. It also enhances the effect of serotonin, histamine, oxytocin, acetylcholine on smooth muscle. The use of Axamon helps to restore the peripheral nervous system, which has been damaged by the use of antibiotics, local antiseptics, toxins, inflammation or injury. The drug tones the muscles of the internal organs, reduces the heart rate, increases the process of salivation, improves memory, stimulates the central nervous system. Aksamon is often used by students and schoolchildren, as it improves concentration and helps to cope with mental stress.
Release form and composition
The main active ingredient in the preparation is ipidacrine hydrochloride monohydrate, in solution for injections there are auxiliary components: hydrochloric acid solution, water for injections. Form of Axam - tablets and injection.
The solution for subcutaneous or intramuscular administration is packed in 5 and 15 mg ampoules. It looks like a clear liquid without sediment. The tablets are packaged in vials of 50 pieces each.
Indications for use of Axamon
The use of Axamon in the following diseases is shown: neuritis, multiple sclerosis, myasthenia, Alzheimer's disease, polyneuritis, myasthenic syndrome, neuropathy, encephalopathy, cerebral circulatory disorder, myelorapiradiculoneuritis, bulbar paralysis and movement disorders. The use of Axamon helps to get rid of such functional disorders of the nervous system as low concentration of attention, memory impairment, disorientation, lability, loss of initiative and motivation. Aksamon is a part of complex therapy for demyelinating diseases, traumatic brain injuries and poisoning with anticholinergics. Also, the drug is prescribed to children and adolescents who have learning difficulties and cerebral dysfunction. Sometimes Aksamon used with weak labor and intestinal atony.
The instructions to Axamon indicate that contraindications for use are angina, bronchial asthma, epilepsy, severe bradycardia, hypersensitivity to the drug, vestibular and extrapyramidal disorders, pregnancy and breastfeeding. Under constant medical supervision, Axamon should be taken in patients with cardiovascular diseases, gastrointestinal ulcer and thyrotoxicosis. During treatment, it is strictly forbidden to consume alcohol; it is not recommended to engage in activities requiring increased attention and concentration.
Dosage and administration of Axamon
According to the instructions to Axamon, the drug is taken orally or make subcutaneous and intramuscular injections. For the treatment of myasthenic syndrome, myasthenia, demyelinating disorders of the nervous system, you should take an increased dose of the drug - 20-40 mg 5-6 times a day. The maximum daily dosage for an adult is 200 mg. In the treatment of diseases of the peripheral nervous system, 20 mg is prescribed 3 times a day. For the treatment of Alzheimer's disease, the dosage is adjusted individually by the doctor. The course of treatment ranges from one month to one year, depending on the severity of the disease.
When myasthenic crisis Aksamon should be used in the form of injections of 5-15 mg 1-2 times a day. For the treatment of intestinal atony appoint 15-20 mg three times a day, the course is 2 weeks. When stimulating the genera Aksamon apply 20 mg 1-3 times with an interval of 1 hour.
Side Effects of Axamon
Reviews of Axamon claim that the drug is easily tolerated. Side effects include jaundice, nausea, anorexia, diarrhea, dizziness, loss of appetite, vomiting, pruritus, rash, bronchospasms, bradycardia.
When treating Aksamon should consider a possible increase in the tone of the uterus. Studies have shown that side effects are extremely rare, in about 6.5% of cases. As a rule, they are mild and do not require discontinuation of the drug. Aksamon should be carefully combined with other drugs. Thus, simultaneous use with cholinergic agents increases the risk of a cholinergic crisis in patients with myasthenia. Aksamon weakens the effect of potassium chloride, local antiseptics and antibiotics. When combined with beta-blockers increases the likelihood of developing bradycardia. Aksamon increases the strength of m-cholinomimetics and drugs that depress the central nervous system.
Analogs of Axamon
Analogues of Aksamon are drugs Amiridin, Ipidakrin, Neyromidin.
Terms and conditions of storage
The drug should be stored in a dark dry place at a temperature not higher than 25 ° C for two years. It is released in pharmacies without a doctor's prescription.