Akkupro is an ACE inhibitor.
Release form and composition
Akkupro is available in the form of film-coated tablets, each tablet has a number corresponding to its active substance content - hinapril (5 mg, 10 mg, 20 mg or 40 mg). As auxiliary substances, the drug contains magnesium stearate, gelatin, magnesium carbonate, crospovidone, lactose monohydrate. The composition of the film shell of the tablets include: opadry white OY-S-7331 and herbal wax.
Indications for use Akkupro
According to the instructions to Akkupro, indications for the use of the drug are:
- Arterial hypertension (the drug is used as monotherapy or in combination with beta-blockers and thiazide diuretics);
- Chronic heart failure (in combination therapy);
Contraindications to Akkupro
The drug Akkupro is contraindicated to take children and adolescents up to 18 years, patients with angioedema in history, which is associated with therapy with ACE inhibitors, and when the patient is hypersensitive to any component of the drug.
Akkupro is prescribed with caution in the presence of angioedema in history, if it is not associated with the use of ACE inhibitors, with severe heart failure with a high risk of severe hypotension, with hyperkalemia, reduced BCC volume, aortic stenosis, condition after kidney transplantation, bone marrow hematopoiesis depression, severe autoimmune diseases of connective tissue, diabetes mellitus, abnormal liver or kidney function, and extensive surgical interventions.
Administration and dosage Akkupro
In the treatment of arterial hypertension, patients who do not receive diuretics are prescribed 10 or 20 mg of the drug 1 time per day. The dose may be increased depending on the clinical effect. Maintenance dose - 20 or 40 mg per day, usually given in one or two doses. The dose changes at intervals of four weeks. In most cases, it is possible to achieve adequate blood pressure control during long-term therapy by applying Akkupro 1 time per day. The maximum permissible daily dose is 80 mg.
Patients who continue to receive diuretics, first prescribed 5 mg of the drug, after which the dose is increased until the optimal effect is achieved.
The use of Akkupro in patients with chronic heart failure is indicated as part of a combination therapy with diuretics and / or cardiac glycosides. In this case, the initial dose is 5 mg 1 or 2 times a day. If the tolerability of the drug is good, the dose can be increased to 10-40 mg per day in 2 equal doses.
It is recommended to start Akkupro therapy in patients suffering from renal dysfunction with 5 mg of the drug 1 time per day. The next day, if the tolerance of the initial dose is good, you can prescribe two doses per day. In the absence of impairment of renal function or hypotension, the dose can be increased at weekly intervals.
In patients in old age, the recommended initial dose is 10 mg 1 time per day. Subsequently, it may increase to achieve the optimal therapeutic effect.
Side effects Akkupro
According to the instructions to Akkupro, when it is applied, undesirable phenomena are usually mild and transient. Dizziness, fatigue, cough, headaches, rhinitis, myalgia, nausea and / or vomiting are most common. Coughing is typically persistent, unproductive. After cessation of therapy, he passes.
All other adverse events are observed in 0.5-1% of patients:
- Anaphylactic reactions;
- Hemolytic anemia;
- Weakening of vision;
- Increased excitability;
- Dry throat or mouth;
- Angina pectoris;
- Postural hypotension;
- Increased sweating;
In rare cases, when using Akkupro, angioedema was observed.
It is noted that when treating with ACE inhibitors, angioedema is possible (0.1% of cases). When an angioneurotic edema of the tongue, face, or epiglottis appears, you should immediately stop the treatment of Akkupro. The patient should be given appropriate therapy and should be monitored until the edema is relieved. Edema of the lips and face in most cases passes without special treatment, but antihistamines can be used to reduce the symptoms. Laryngeal edema can be fatal. If there is a risk of airway obstruction, emergency treatment is required, including the administration of adrenaline and other measures.
In the case of drug treatment, angioedema of the intestines may develop, manifested by abdominal pain without nausea and vomiting. Symptoms completely disappeared after discontinuation of ACE inhibitors.
Patients who receive ACE inhibitors during Hymenophera poison therapy may develop life-threatening anaphylactic reactions. In patients taking diuretics, the appointment of Akkupro can cause the development of symptomatic arterial hypotension. If the patient needs diuretic therapy, it should be discontinued 2-3 days before the start of Akkupro.
In hypertensive patients suffering from unilateral or bilateral stenosis of the renal artery, Akkupro treatment can lead to an increase in serum creatinine and urea nitrogen in the blood. Such changes disappear after drug withdrawal. In this case, kidney function should be monitored during the first few weeks of treatment.
Analogs of Akkupro
Analogues of the drug are drugs Akurenal and Quinafar.
Terms and conditions of storage
According to the instructions to Akkupro, the drug should be kept out of the reach of children. Storage temperature - not higher than 25 ° С. The shelf life of the drug is 3 years.