Akineton is an anti-parkinsonian drug, an inhibitor of cholinergic transmission in the central nervous system.
Release form and composition
Akinet is available in the form of tablets, each of which contains 2 mg of the active substance - biperidine hydrochloride. Auxiliary substances are: lactose monohydrate, corn starch, calcium hydrophosphate dihydrate, MCC, talc, copovidone, purified water and magnesium stearate.
Indications for use
According to the instructions for Akineton, indications for use are:
- Parkinson's syndrome in adults;
- poisoning with phosphorus-containing substances or nicotine in adults;
- extrapyramidal symptoms in adults and children, caused by neuroleptics and drugs acting similarly.
The use of Akineton is contraindicated in:
- gastrointestinal obstruction;
- angle-closure glaucoma;
- gastrointestinal stenosis;
- hypersensitivity to the drug.
Akineton can not be taken by children under the age of three years. With caution, the drug is prescribed for urinary retention, prostatic hyperplasia, cardiac arrhythmias, as well as for patients prone to epileptic seizures and elderly patients.
Dosing and Administration
The drug should be taken during or after a meal with a liquid.
When prescribing Akineton treatment usually begin with small doses, and then gradually increase them, depending on the presence of side effects and therapeutic action.
In parkinsonism, adults are prescribed 1 mg of the drug 1-2 times a day. Every day, the dose may be increased by 2 mg. The maximum daily dose is 16 mg. The total daily dose is evenly distributed for administration throughout the day.
When motor disorders are caused by the action of drugs, adults are prescribed 1-4 mg 1-4 times a day, depending on the severity of the symptoms. Children under 15 years old - 1-2 mg 1-3 times a day.
When drug dystonia in children usually apply short courses of treatment with Akineton.
Taking pills immediately after a meal can reduce unwanted effects on the gastrointestinal tract. The duration of use of Akineton depends on the type of disease. When it is canceled, the dose is reduced gradually.
The instructions for Akineton indicate several groups of side effects observed when taking this drug.
On the part of the central nervous system: drowsiness, dizziness, fatigue, weakness, confusion, anxiety, impaired memory, euphoric state, headache, nervousness, insomnia, ataxia, delirious disorders, and in some cases hallucinations. With increased excitation of the nervous system, it is necessary to reduce the dose of the drug.
On the part of the organs of vision: mydriasis, accommodation paresis, angle-closure glaucoma.
Since the cardiovascular system: bradycardia and tachycardia, low blood pressure.
On the part of the digestive system: dry mouth, nausea, increased salivary glands, epigastric discomfort, constipation.
On the part of the urinary system: difficulty urinating (especially with prostatic hyperplasia), urinary retention.
Others: drug dependence, reduction of sweating, allergic reactions.
Most often, side effects are observed during the use of Akineton in the early stages of treatment. Abrupt withdrawal of this drug should be avoided, except in cases that threaten the patient’s life.
Elderly patients may show increased sensitivity to the drug, especially in those who suffer from cerebral disorders of a vascular or degenerative nature.
Medications of central action can increase a patient's susceptibility to seizures. For this reason, the treatment of patients with this predisposition requires special care.
In case of the development of tardive dyskinesia, the parkinsonian symptoms can be so severe that they interfere with the treatment with anticholinergic drugs.
With prolonged therapy with Akineton, one should regularly check intraocular pressure to prevent the development of angle-closure glaucoma.
Akineton, especially when combined with other centrally acting drugs and anticholinergics, can lead to impaired ability to drive and work with complex mechanisms.
Marked abuse drug. Perhaps this phenomenon is due to the fact that in some cases it leads to improved mood and temporary euphoric effects. Akineton can be purchased only on prescription.
Analogs of this drug are drugs Cyclodol, Biperiden and Mendilex.
Terms and conditions of storage
The shelf life of the drug is 5 years. According to the instructions to Akineton, it should be kept out of the reach of children, at a temperature not higher than 25 degrees.