Akatinol is a muscle relaxant drug that affects the central nervous system.
Release form and composition
Akatinol tablets are made, film-coated, biconvex, white, oblong, in a package of 30 or 90 pieces. The active substance of the drug is memantine hydrochloride - 10 mg. Auxiliary components are microcrystalline cellulose, lactose, magnesium stearate, talc, colloidal silicon dioxide.
Also produce drops Akatinol, intended for oral administration, in vials of 50 or 100 ml. The active substance drops - memantine hydrochloride 10 mg. Auxiliary components are sorbitol solution, purified water, potassium sorbate.
Indications for use Akathinol
According to the instructions, Akatinol is shown in the following cases:
- Degenerative dementia of the Alzheimer's type;
- Mixed dementia of any severity;
- Vascular dementia;
- Cerebral and spinal spastic syndrome resulting from traumatic brain injury, stroke, multiple sclerosis;
- The weakening of the ability to concentrate attention, memory, ability to learn.
According to the instructions, Akatinol should not be taken in the following cases:
- Period of pregnancy and lactation;
- Hypersensitivity to the main or auxiliary components of the drug;
- Severe renal dysfunction;
- Children's age up to 18 years.
Patients with epilepsy and thyrotoxicosis should be careful when using Akatinol.
Dosing and Administration Akatinol
According to the instructions, Akatinol is indicated for oral administration. The dosage regimen is set individually. It is recommended to start treatment with the drug with minimal dosages.
In dementia syndrome, adult patients are prescribed 5 mg of the drug per day for one week, during the second week the dosage of Akatinol is 10 mg per day, and the third 15-20 mg per day. If necessary, a further increase in the dose of 10 mg weekly is allowed up to a maximum of 30 mg per day.
For disorders of motor functions due to pathology of the central nervous system, patients are prescribed Acatinol at a dose of 10 mg per day during the first week, with a weekly increase in dosage to 30 mg per day. In case of emergency, a weekly dose increase to 60 mg per day is allowed.
Maintenance dosage of Acatinol is 10-20 mg per day.
The daily dosage of medication should be divided into several doses. Take the drug during the meal, and the last dose should be taken before dinner.
In cases of impaired renal function, the dosages of Akatinol are determined individually, depending on the therapeutic efficacy. It is recommended to undergo regular monitoring of renal function.
Side Effects of Acatinol
The use of Akatinol can cause the following side effects from various life systems:
- Mind: drowsiness, hallucinations, confusion, psychotic reactions;
- Cardiovascular system: thromboembolism, arterial hypertension, heart failure;
- Nervous system: dizziness, convulsions, gait disturbance;
- The digestive system: vomiting, nausea, constipation, pancreatitis;
- Respiratory system: shortness of breath;
- From the whole body: fatigue, headache, fungal infections.
It should be noted that during the treatment with Akatinol, hallucinations were observed mainly in patients who are in a severe stage of dementia.
Elderly patients prefer to take medicine in the form of drops. The optimal dosage of Akathinol drops is also achieved gradually, with a weekly increase.
Akatinol enhances the action of anticholinergics, levodopa, dopamine agonists with their simultaneous use.
Akatinol reduces the effects of neuroleptics and barbiturates with their simultaneous use.
When Akatinol is combined with batrafen or dantrolene, it is possible to both strengthen and weaken the action of the latter, therefore, the dosage of drugs should be carefully adjusted.
Combinatorial use of Akatinol with ketamine, amantadine, dextromethorphan is not recommended.
When taking Akatinol in excessive dosages may increase the side effects of the drug. In this case, it is recommended to do a gastric lavage, take adsorbents and conduct symptomatic therapy.
In principle, patients with Alzheimer's disease at the stage of moderate or severe dementia cannot fully manage complex mechanisms that require increased concentration of attention. Akatinol in this case is also capable of causing a change in the reaction rate, therefore patients undergoing medication treatment are not recommended to drive a car or control other life-threatening mechanisms.
Analogs of Akatinol
The following drugs are analogues of Akatinol: Memantine, Maruksa, Alzeim, Memantinol, Memantine hydrochloride, Noodgeron, Memorial, Memedar.
Terms and conditions of storage
According to the instructions, Akatinol refers to a list of drugs from pharmacies prescription.
It is recommended to store the medicine in a dark and cool place out of the reach of children.
The shelf life of tablets is 3 years, drops - 5 years.