Agapurin is an angioprotective drug that improves microcirculation.
Release form and composition
Available Agapurin in the form of:
- Tablets and tablets of prolonged action, each of which contains 100, 400 or 600 mg of pentoxifylline and such excipients as lactose monohydrate, talc, anhydrous colloidal silicon, corn starch, magnesium stearate;
- Injection solution, in 1 ml of which contains 20 mg of pentoxifylline (in one ampoule - 100 mg), as well as injectable water and sodium chloride as auxiliary substances.
Indications for use Agapurina
The official instructions for Agapurin indicate that this drug is intended for the treatment of:
- Peripheral circulatory disorders, including with obliterating endarteritis and intermittent claudication caused by diabetic angiopathy or atherosclerosis;
- Violations of tissue trophism (with frostbite, gangrene, trophic ulcers, varicose veins, post-thrombotic syndrome);
- Acute and chronic disorders of cerebral circulation of ischemic origin;
- Cerebral atherosclerosis, manifested by impaired memory, headache, dizziness, sleep disturbance;
- Circulatory disorders in the vessels of the eye (in acute or chronic circulatory failure in the choroid and retina);
- Conditions after ischemic or hemorrhagic stroke;
- Violations of the function of the middle ear of vascular origin, accompanied by hearing loss;
- Dyscirculatory encephalopathy;
- States after myocardial infarction;
- Viral neuroinfection (in order to prevent microcirculation disorders);
- Coronary heart disease;
- Bronchial asthma and chronic obstructive pulmonary disease;
- Organic impotence vascular origin.
As indicated in the instructions for Agapurin, this drug should not be used:
- In the presence of hypersensitivity to pentoxifylline, any of the auxiliary components of the drug or other xanthine derivatives;
- Patients with acute myocardial infarction;
- With massive bleeding;
- Patients with hemorrhagic stroke;
- With retinal hemorrhage;
- Pregnant women;
- During lactation.
Intravenous administration of the solution Agapurin, except for the cases described, is contraindicated in severe atherosclerosis of the cerebral or coronary arteries, arrhythmias, uncontrolled arterial hypotension.
It is possible to use Agapurin, but with great care and under constant medical supervision:
- In chronic heart failure;
- People with labile blood pressure (or rather, with a tendency to arterial hypotension);
- Patients with gastric ulcer or 12 duodenal ulcer (for tablet form of the drug);
- With hepatic / renal failure;
- Patients who have recently undergone surgery;
- Children and adolescents under 18 years old (due to the lack of sufficient data on efficacy and safety).
Dosage and Administration Agapurina
Agapurin tablets are taken orally after a meal, preferably at the same time. The initial dosage is usually 200 mg three times a day. Patients who have long-term treatment, as well as those who have severe hypotension or symptoms of irritation of the gastrointestinal tract or the central nervous system, reduce the dosage to 100 mg three times a day. The maximum allowable daily dosage is 1200 mg.
Tablets of prolonged action is prescribed for 1 pc. two or three times a day.
The solution Agapurin can be administered intramuscularly, intravenously or intraarterially. The procedure is carried out necessarily in the position of the patient lying down.
Intravenously, the drug is usually administered in an amount of 100 mg (which corresponds to 1 ampoule), dissolved in 250-500 ml of 5% dextrose solution or 0.9% sodium chloride solution, for 1.5-3 hours drip. With good tolerability of Agapurin, the dose can be doubled, with a maximum of 300 mg.
On the first day, 100 mg of Agapurin is injected intraarterially, dissolving them in 20-50 ml of sodium chloride solution, then 200-300 mg each, diluted with 30-50 ml of solvent. The duration of the injection is 10 minutes. Patients with severe atherosclerosis of the cerebral vessels are prohibited from entering the solution into the carotid artery.
Intramuscular Agapurin is administered 100 mg once or twice a day.
Dosage adjustment in the lower side (approximately 30-50%) is required for people with insufficient kidney function (with a CC of more than 400 mmol / l).
Side Effects of Agapurin
According to reviews, on the background of the use of Agapurin, the development of such negative reactions on the part of the body, such as:
- Sleep disturbance, dizziness or headache, anxiety;
- Hyperemia of the skin, swelling, flushing to the skin of the upper chest, increased fragility of the nails;
- Decrease in blood pressure, cardialgia, arrhythmia, tachycardia, rarely - worsening of symptoms of angina pectoris;
- A feeling of heaviness in the stomach, nausea, intestinal atony, vomiting, loss of appetite, bleeding from the intestines or mucous membranes of the stomach, exacerbation of cholecystitis;
- Visual impairment, the appearance of blind spots in the field of view;
- Thrombocytopenia, hypofibrinogenemia, pancytopenia, leukopenia, bleeding from skin vessels.
Also Agapurin, according to reviews, can cause allergic reactions, manifested by redness of the skin, itching, urticaria, edema, anaphylactic shock.
Analogs of Agapurina
According to belonging to the same pharmacological group and the similarity of the mechanisms of action, the following drugs are the analogues of Agapurin: Arbiflex, Vazonit, Kinetal-400, Acepentate, Dartelin, Pentohexal, Pentamon, Mellinorm, Pentlin, Pentox-400, Pentoxifillin, Pentoxal, Pentoxal, Pentoxal, Pentoxal, Pentoxal, Pentoxal, Pentoxal, Pentoxal, Pentoxal, 400 Trental, Hinothal, Flexital.
Terms and conditions of storage
It is recommended to store Agapurin in a dry, protected from direct sunlight and a cool place at a temperature: 15-25 ºС - in the form of tablets, 10-25 ºС - in the form of a solution.
The shelf life of tablets Agapurin - 5 years, the solution - 3 years.