Acetylsalicylic acid (ASA) is a nonsteroidal anti-inflammatory drug.
Release form and composition
The drug is produced in the form of tablets containing the same active ingredient, in a dosage of 100 mg, 250 mg and 500 mg.
Indications for use
As indicated in the instructions for acetylsalicylic acid, indications for use of the drug are:
- Febrile syndrome due to infectious and inflammatory diseases;
- Pain syndrome: migraine, headache (including against the background of alcohol withdrawal syndrome), toothache, chest root syndrome, algomenorrhea, arthralgia, neuralgia, myalgia, lumbago.
At dosages up to 300 mg per day, acetylsalicylic acid is prescribed as an antiplatelet drug for:
- Ischemic heart disease or the presence of several risk factors that predispose to its development;
- Unstable angina pectoris;
- Painless myocardial ischemia;
- Myocardial infarction (to prevent recurrence and reduce the risk of death after it);
- Repeated transient cerebral ischemia and ischemic stroke in men;
- Pulmonary infarction;
- Stenting and balloon coronary angioplasty (to reduce the risk of re-stenosis and to treat secondary coronary artery dissection);
- Takayasu disease (aortoarteritis);
- Recurrent pulmonary embolism;
- Kawasaki disease (non-atherosis of the coronary artery);
- Mitral valve prolapse (for the treatment and prevention of thromboembolism);
- Valvular mitral heart disease;
- Atrial fibrillation;
- Dressler's syndrome (post-infarction syndrome);
- Acute thrombophlebitis.
In addition, acetylsalicylic acid, according to the instructions, is used in allergology and clinical immunology: gradually increasing the dose, it is prescribed for prolonged aspirin desensitization (desensitization) and the formation of tolerance to nonsteroidal anti-inflammatory drugs in patients with aspirin triad and aspirin asthma.
According to the annotation to the drug, the use of acetylsalicylic acid is contraindicated in:
- Hepatic / Renal Failure;
- Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
- Gastrointestinal bleeding;
- Vitamin K deficiency;
- Hemorrhagic diathesis (thrombocytopenic purpura, thrombocytopenia, Willebrand disease, hypoprothrombinemia, telangiectasia, hemophilia);
- Aspirin triad in combination with bronchial asthma, recurrent nasal polyposis and paranasal sinuses or intolerance to the pyrazolone and ASK preparations;
- Deficiency of glucose-6-phosphate dehydrogenase;
- Portal hypertension;
- Aortic aneurysm.
Do not take the drug:
- Pregnant women, especially in the first and third trimesters;
- During lactation;
- Children and adolescents up to 15 years.
With caution, ASA is prescribed to patients with:
- Bronchial asthma;
- Kidney / liver disease;
- Erosive and ulcerative lesions of the digestive tract;
- Decompensated chronic heart failure;
- Increased bleeding;
- The history of bleeding from the gastrointestinal tract;
- Simultaneous anti-coagulation therapy.
Dosing and Administration
The dose and duration of use of acetylsalicylic acid is determined by the doctor, taking into account the indications. A single dose may vary from 40 to 1000 mg, daily - from 150 mg to 8 grams. The total daily dose is divided into 2-6 doses.
With pain and feverish syndrome take 0.5-1 g per day for 2-3 doses.
Without coordination with the doctor, the drug should not be taken for more than 3 days as a febrifuge and for longer than 7 days as an anesthetic.
Reviews of patients taking ASA indicate that this drug may have side effects, such as:
- Nausea, vomiting, diarrhea, epigastric pain, anorexia, rarely - bleeding from the gastrointestinal tract, erosive and ulcerative lesions of the gastrointestinal tract, abnormal liver function (on the part of the digestive system);
- Tinnitus, dizziness, reversible visual disturbances, headache, aseptic meningitis (with prolonged use, from the side of the central nervous system);
- Rarely - anemia, thrombocytopenia, lengthening of the bleeding time, hemorrhagic syndrome (from the side of the hematopoietic system and the blood coagulation system);
- Rarely - functional disorders of the kidneys, with long-term use - nephrotic syndrome, acute renal failure (from the urinary system);
- Skin rash, bronchospasm, angioedema, aspirin triad.
Children under 15 years of age with viral diseases Acetylsalicylic acid can trigger the development of Reye's syndrome - a rare but dangerous and often life-threatening condition, accompanied by productive vomiting, hyperthermia, disorientation, confusion, agitation, liver enlargement, convulsions and coma.
During the period of treatment with drugs that include ASA, you should refrain from the use of alcoholic beverages.
If it is necessary to use the medication for a long time, it is necessary to periodically perform a general blood test and examine the feces for hidden blood.
Analogues of acetylsalicylic acid are the following drugs:
- According to the active substance: Aspinat, Aspivatrin, Aspitrin, Aspirin, Asprovit, Atsbirin, Nekstream Fast, Taspir, Upsarin Upsa, Fluspirin;
- According to the mechanism of action: Akvazitramon, Askofen-P, Aspagel, Aspivit, Aspinat plus, Ascelisin, Acepar, Kofitsil Plus, Migrenol Extra, Parcocet, Salicylamide, Cefecone N, Citramon II, Citramon Acri, Tsitrapak, Citrapar Ac, Citrapac, Citrapar Ac, Citrapac, Citrapon Ac, Cetracone N, Citramon P.
Terms and conditions of storage
Acetylsalicylic acid is a drug that can be bought at a pharmacy without a doctor's prescription. Its shelf life is 4 years if it is stored in a dry, cool, sun-protected place. Keep out of the reach of children!