Aceklidine - M-cholinomimetic, stimulating M-cholinergic receptors, increasing the tone and enhancing the contraction of the uterus, intestines and bladder, as well as causing miosis (constriction of the pupil) and reducing intraocular pressure.
Release form and composition
Available in the form of the drug:
- 0.2% solution, intended for subcutaneous administration, in 1 and 2 ml ampoules;
- 3% and 5% eye ointment in tubes of 20 g.
The active component of aceclidine is the same substance.
Indications for use
As indicated in the instructions for aceclidine, in the form of injections, this drug is used:
- With subinvolution of the uterus (reduced its reduction after childbirth);
- When atony (violation of normal tone) of the bladder and gastrointestinal tract;
- To stop bleeding in the postpartum period;
- In preparing the patient for X-ray examination of the stomach, duodenum and esophagus.
In the form of an eye ointment, Aceclidine, according to the instructions, is prescribed to reduce intraocular pressure and constriction of the pupil in glaucoma.
According to the annotation to the drug, the use of aceclidine is contraindicated in:
- Bronchial asthma;
- Angina pectoris;
- Epilepsy and propensity for convulsions;
- Chronic heart failure of the second and third stages;
- Bleeding from the gastrointestinal tract;
- The presence before the operation of inflammatory processes in the abdominal cavity;
- Pregnancy (unless it is necessary to increase the tone of the myometrium);
- The presence of hypersensitivity to aceclidine or any auxiliary component.
Dosing and Administration
Aceclidine solution, according to the instructions, is intended for subcutaneous administration. The dosage of the drug prescribed by the doctor, taking into account the indications and the overall clinical situation.
With subinvolution of the uterus, atony of the bladder and stomach, as a rule, 1-2 ml of solution is injected. If necessary, make another 2-3 injections at intervals of 30 minutes, with hypotension of the uterus - within 2-3 days. The maximum permissible dose for adults: single - 4 mg, daily - 12 mg.
Before examining the esophagus to identify achalasia (motility disorders characterized by weakening of peristalsis and incomplete relaxation of the lower esophageal sphincter during swallowing), if it is caused by parasympathetic denervation, the solution is injected in a volume of 0.75-1 ml 15 minutes before taking a barium suspension.
To clarify the nature of the damage to the duodenum and stomach, a solution in a volume of 0.5-1 ml is injected after the usual X-ray examination, after 15 minutes an additional portion of barium suspension is taken, after which a second examination is carried out.
Aceclidine eye ointment is laid at the edges of the eyelids once a day - before going to bed.
Patient reviews indicate that in most cases, this drug is well tolerated. However, in some cases, there are complaints about the development of such adverse reactions caused by the use of aceclidine, such as:
- After subcutaneous administration: hyperhidrosis, increased salivation, diarrhea;
- When applied topically in ophthalmology: a feeling of heaviness and aches in the eyes, vascular injection, slight irritation of the conjunctiva.
In individual cases, in the presence of hypersensitivity or intolerance to one or another component of aceclidine, allergic reactions may develop. If any adverse events occur with the use of this medication, it should be reported to your doctor.
When using aceclidine in too high doses (significantly higher than those recommended by a doctor), the appearance or enhancement of existing side effects may occur, as well as a slight decrease in blood pressure with bradycardia. Such a patient should be administered Metacin, Atropine or another M-anticholinergic.
In ophthalmic practice, if necessary, Aceclidine can be combined with other miotikami.
You should not simultaneously use this drug with M-holinoblokatorami, because they inhibit the effect of aceclidine.
Analogues of this drug for use in ophthalmology are Glaunorm, Glaudin and Glaukostat.
The similarity of action of analogues aceclidine solution can assume the following drugs: Ganaton, Damelium, Dimetpramid, Dometius, Domperidone, Domstal, Itomed, Itopra, Melomida, metoclopramide, Motizhekt, Motilak, Motilium, Motinorm, Motonium, Passazhiks, Perinorm, Tseruglan.
Terms and conditions of storage
Aceclidine is a drug that is dispensed from pharmacies strictly on prescription and belongs to the A list of medicinal products that are included in the State Pharmacopoeia as poisonous and narcotic, whose storage and use must be done according to special rules due to their high toxicity and ability to cause addiction. For example, aceclidine should be stored separately from other medications, under lock and key, and protected from sunlight and in a cool place.
The shelf life of the solution is 2 years, ointment - 1 year.