Atsefen is a central nervous system stimulant that helps normalize the activity of the brain and nerve cells.
Release form and composition
- Acefen tablets 100 mg, 50 pieces per pack;
- Injection Atsefen vials 250 mg, 10 pieces per pack.
The active ingredient of acephene is meclofenoxate.
Indications for use
According to the instructions, Acefen is indicated for:
- Asthenia (a disease accompanied by increased fatigue, depletion of the body and an extremely unstable mood);
- Asthenoipochondria (symptoms - depression, weakness);
- Various neurotic disorders;
- Violation of cerebral circulation;
- Astheno-depressive conditions, accompanied by weakness and depressed mood;
- Diencephalic syndrome (dysfunction of the medulla oblongata);
- The retardation of the mental development of children;
- Obsessional neurosis (obsessive states);
- Dyscirculatory encephalopathy (progressive vascular lesion, characterized by a decrease in the supply of brain tissue);
- Amyotrophic lateral sclerosis (progressive chronic nerve damage);
- Vascular and traumatic diseases of the brain, including in patients of childhood and adolescence;
- Violation of mnestic functions (in old age or with brain lesions).
According to the instructions, Atsefen is not prescribed to patients with:
- Hypersensitivity to meclofenoxate or auxiliary components of the drug;
- Infectious diseases of the central nervous system;
The use of Atsefen is not recommended for pregnant women and lactating babies, unless the potential benefits to the mother outweigh the possible risks to the health of the fetus or baby.
Dosing and Administration
Acefen tablets are administered orally, three times a day. The optimal time of admission - after a meal, but the last pill is recommended to take no later than 16.00. The fact is that the medicine stimulates the central nervous system, and this can provoke insomnia and other sleep disorders in the patient.
Standard daily dosages of Atsefen are 250-500 mg for adults, 200-400 mg for children.
Atsefen injections are given intravenously or intramuscularly. Solutions should be prepared immediately before use on sterile isotonic sodium chloride solution.
The duration of therapy with acephen is 1-3 months. The clinical effect of treatment is observed 2 weeks after starting the medication.
The use of Atsefen is predominantly tolerated by patients. Most adverse reactions are unexpressed and pass quickly.
The most common side effects of Atsefen are:
- Abdominal pain;
- Increased appetite;
- Allergic skin reactions;
In patients with schizophrenia, Atsefen may cause increased anxiety and delusions, an increase in the frequency of hallucinations, and an increase in fear.
During the application of Atsefen, patients should be closely monitored with symptoms of gastrointestinal disturbances, hemorrhagic diathesis, Crohn's disease, and hematological disorders. In elderly people, gastrointestinal bleeding, perforated ulcers have more serious consequences and can manifest at any time of treatment, especially with a history of these diseases. At the first symptoms of gastrointestinal disorders, treatment with acephenus should be discontinued.
Patients with severely impaired liver function, treatment with Atsefen should be started with a dose of 150 mg per day and its function should be monitored throughout the therapy.
During the application of Atsefen, it is recommended to refrain from driving vehicles and controlling machinery requiring high concentration of attention.
Like other nonsteroidal anti-inflammatory drugs, acephene can increase the plasma concentration of digoxin and lithium.
The combination of Atsefen with methotrexate should be avoided, since an increase in the toxicity of the latter and an increase in its plasma level are not excluded.
The combination of acephenol with acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs can increase the frequency and severity of side effects.
The following drugs are analogues of Atsefen as belonging to the same pharmacological group and to similar therapeutic effects:
- Ginkgo biloba;
Terms and conditions of storage
According to the instructions, Acefen is a drug dispensed from pharmacies with a prescription. Store the drug is recommended in a cool, dry, protected from sunlight. The shelf life of the drug - 3 years.