Abactal is an antibacterial drug belonging to the group of fluoroquinolones.
Release form and composition
Abaktal is produced in the form of coated tablets, a solution for iv administration and a concentrate for preparing such a solution.
Each tablet contains:
- 400 mg pefloxacin;
- Such excipients: talc, corn starch, lactose monohydrate, sodium carboxymethyl starch, magnesium stearate, anhydrous colloidal silicon dioxide;
- The shell includes: talc, carnauba wax, titanium dioxide, macrogol, hypromellose.
In 5 ml of the solution prepared from a concentrate, and also in one ampoule of ready solution contains:
- 400 mg pefloxacin;
- Excipients: sodium bicarbonate, benzyl alcohol, sodium metabisulphite, ascorbic acid, disodium edetate, injectable water.
Indications for use Abaktala
As stated in the official instructions for Abactal, this antibiotic is intended for the treatment of infectious diseases caused by microorganisms sensitive to pefloxacin. In particular, for the treatment of infections:
- Kidney and urinary tract;
- Pelvic organs (including prostatitis and adnexitis);
- Lower respiratory tract;
- Liver, biliary tract and gallbladder (bladder empyema, cholecystitis, cholangitis);
- ENT organs (larynx, pharynx, sinuses, middle ear);
- Abdominal cavity (peritonitis and intra-abdominal abscesses);
- Gastrointestinal (including typhoid and salmonellosis);
- Joints, bones and connective tissue (including osteomyelitis);
- Skin and soft tissue (including diseases caused by staphylococcus resistant to penicillin).
Also Abaktal, according to the instructions prescribed for the treatment of:
- Meningeal infections, including meningoencephalitis;
- Bacterial endocarditis;
- Soft chancre;
Proved the effectiveness of the use of Abaktal for the prevention and treatment of nosocomial and surgical infections, as well as to prevent the development of infectious diseases in patients with immunodeficiencies.
The drug can be administered both as monotherapy and in combination with other antimicrobial agents.
The use of Abaktala, according to the instructions, is contraindicated:
- In the presence of hypersensitivity to pefloxacin or some auxiliary component;
- With a deficiency of glucose-6-phosphate dehydrogenase;
- Patients with hemolytic anemia;
- Children and teenagers under 18;
- Pregnant women;
- During lactation.
Abaktal is prescribed, but with caution and under constant medical supervision for patients with:
- Atherosclerosis of cerebral vessels;
- Epileptic syndrome of unknown genesis;
- Organic lesions of the central nervous system;
- Violation of cerebral circulation;
- Severe liver failure;
- Combined renal and hepatic insufficiency.
Administration method and dosage of Abaktal
Abaktal tablets are taken orally on an empty stomach. The specific dosage is selected by the doctor individually for each patient, depending on the type and location of the infection, the severity of the course of the disease, the sensitivity of microorganisms. With uncomplicated infections, as a rule, 1 tablet is prescribed twice a day.
Abaktal solution is intended for intravenous drip in severe infections, sepsis, infective endocarditis. The first dose is usually 800 mg, then every 12 hours a 400 mg infusion is given. Enter the drug within one hour, the contents of the ampoule are pre-dissolved in 250 ml of 5% dextrose solution. The duration of treatment with Abaktal is 1-2 weeks.
In order to prevent surgical infections, 400 or 800 mg of the drug is administered to the patient one hour before the operation.
Patients who have impaired liver function, the drug is prescribed in the same dose - 400 mg, but increase the interval between intake / administration: if the violations are minor, Abactal is used once a day, with more pronounced disorders - once every 36 hours, with severe liver pathologies - once every two days.
Dose adjustment is required for patients with impaired renal function (in which creatinine clearance is below 20 ml per minute) - they are prescribed 200 mg twice a day or 400 mg once a day.
Reduce the dosage of Abaktal and elderly patients by about 1/3.
Side effects of Abaktala
As I testify to the reviews about Abaktal, this antibiotic can provoke the development of side effects, expressed in the form of:
- Dyspepsia, nausea, diarrhea, vomiting, loss of appetite, changes in taste, increased levels of bilirubin, pseudomembranous colitis (rare);
- Anxiety, insomnia, headache, dizziness, blurred vision, hallucinations, depression, increased mental arousal, tremors, confusion;
- Crystaluria, hematuria, interstitial nephritis;
- Arthralgia, myalgia, tendinitis.
Also Abaktal, according to reviews, can cause allergic reactions, manifested by urticaria, skin rash and itching, reddening of the skin, rarely - bronchospasm and photosensitization. When administered intravenously, the development of phlebitis - inflammation of the vein wall is possible.
In order to prevent the development of resistance in the treatment of staphylococcal infections, preparations containing pefloxacin are recommended to be administered simultaneously with beta-lactam antibiotics.
Analogs of Abaktala
According to belonging to the same pharmacological group and mechanism of action, Abactal's analogues are the following drugs: Perflox, Peflobid, Pelox-400, Pefloxacin, Perty, Peflacine, Peflacin, Unicpef.
Terms and conditions of storage
From pharmacies, this antibacterial drug is available on prescription. If the storage conditions recommended by the manufacturer are observed - dry, cool (at a temperature of up to 25 ° C) and protected from direct sunlight, the Abaktal has a shelf life of 3 years.